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Received: 2017-04-24

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.12 P.1113-1122

10.1631/jzus.B1700229


Efficacy of amiodarone and lidocaine for preventing ventricular fibrillation after aortic cross-clamp release in open heart surgery: a meta-analysis of randomized controlled trials


Author(s):  Yong Zheng, Qiang Gu, Hong-Wu Chen, Huai-Ming Peng, Dong-Yu Jia, Yu Zhou, Mei-Xiang Xiang

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   xiangmx@zju.edu.cn

Key Words:  Amiodarone, Lidocaine, Ventricular fibrillation, Open heart surgery


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Yong Zheng, Qiang Gu, Hong-Wu Chen, Huai-Ming Peng, Dong-Yu Jia, Yu Zhou, Mei-Xiang Xiang. Efficacy of amiodarone and lidocaine for preventing ventricular fibrillation after aortic cross-clamp release in open heart surgery: a meta-analysis of randomized controlled trials[J]. Journal of Zhejiang University Science B, 2017, 18(12): 1113-1122.

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author="Yong Zheng, Qiang Gu, Hong-Wu Chen, Huai-Ming Peng, Dong-Yu Jia, Yu Zhou, Mei-Xiang Xiang",
journal="Journal of Zhejiang University Science B",
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number="12",
pages="1113-1122",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700229"
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%T Efficacy of amiodarone and lidocaine for preventing ventricular fibrillation after aortic cross-clamp release in open heart surgery: a meta-analysis of randomized controlled trials
%A Yong Zheng
%A Qiang Gu
%A Hong-Wu Chen
%A Huai-Ming Peng
%A Dong-Yu Jia
%A Yu Zhou
%A Mei-Xiang Xiang
%J Journal of Zhejiang University SCIENCE B
%V 18
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%@ 1673-1581
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700229

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T1 - Efficacy of amiodarone and lidocaine for preventing ventricular fibrillation after aortic cross-clamp release in open heart surgery: a meta-analysis of randomized controlled trials
A1 - Yong Zheng
A1 - Qiang Gu
A1 - Hong-Wu Chen
A1 - Huai-Ming Peng
A1 - Dong-Yu Jia
A1 - Yu Zhou
A1 - Mei-Xiang Xiang
J0 - Journal of Zhejiang University Science B
VL - 18
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SP - 1113
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1700229


Abstract: 
Objective: The relative preventative efficacy of amiodarone and lidocaine for ventricular fibrillation (VF) after release of an aortic cross-clamp (ACC) during open heart surgery has not been determined. This meta-analysis was designed to systematically evaluate the influence of amiodarone, lidocaine, or placebo on the incidence of VF after ACC. Methods: Prospective randomized controlled trials (RCTs) that compared the VF-preventative effects of amiodarone with lidocaine, or amiodarone or lidocaine with placebo were included. PubMed, EMBASE, and the Cochrane Library were searched for relevant RCTs. Fixed or randomized effect models were applied according to the heterogeneity of the data from the selected studies. Results: We included eight RCTs in the analysis. Pooled results suggested that the preventative effects of amiodarone and lidocaine were comparable (relative risk (RR)=1.12, 95% confidence interval (CI): 0.70 to 1.80, P=0.63), but both were superior to the placebo (amiodarone, RR=0.71, 95% CI: 0.51 to 1.00, P=0.05; lidocaine, RR=0.63, 95% CI: 0.46 to 0.88, P=0.006). The percentage of patients requiring electric defibrillation counter shocks (DCSs) did not differ significantly among patients administered amiodarone (RR=0.21, 95% CI: 0.04 to 1.19, P=0.08), lidocaine (RR=2.44, 95% CI: 0.13 to 44.02, P=0.55), or the placebo (RR=0.56, 95% CI: 0.25 to 1.25, P=0.16). Conclusions: amiodarone and lidocaine are comparably effective in preventing VF after ACC, but the percentage of patients who subsequently require DCSs does not differ among those administered amiodarone, lidocaine, or placebo.

胺碘酮和利多卡因对开胸心脏手术中再灌注性室颤预防效果的随机对照试验荟萃分析

目的:系统评估胺碘酮、利多卡因或安慰剂对心脏手术中主动脉结扎松解(ACC)后再灌注性室颤(VF)发生的影响。
创新点:胺碘酮、利多卡因对于预防ACC后再灌注VF的效果,目前相关的随机对照试验(RCTs)并无统一的结论,本研究综合之前RCTs进行荟萃分析。
方法:遵循PRISMA和Cochrane系统评估手册对PubMed、EMBASE及Cochrane进行文献检索 (图1),荟萃分析符合要求的RCTs。
结论:当前的证据表明胺碘酮和利多卡因在开胸心脏手术中预防再灌注VF的效果两者之间并无显著差异,但均明显优于安慰剂;在随后需要电除颤的患者的比例上,胺碘酮、利多卡因及安慰剂三者间无统计学差异。

关键词:胺碘酮;利多卡因;再灌注室颤;心脏手术

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]American Heart Association, 1992. Guidelines for cardiopulmonary resuscitation and emergency cardiac care. JAMA, 268(16):2171-2183.

[2]American Heart Association, 2000. Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Part 6: advanced cardiovascular life support: section 5: pharmacology I: agents for arrhythmias. Circulation, 102(8 Suppl.):I112-I128.

[3]Ayoub, C.M., Sfeir, P.M, Bou-Khalil, P., et al., 2009. Prophylactic amiodarone versus lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamp. Eur. J. Anaesthesiol., 26(12):1056-1060.

[4]Baraka, A., Hirt, N., Dabbous, A., et al., 1993. Lidocaine cardioplegia for prevention of reperfusion ventricular fibrillation. Ann. Thorac. Surg., 55(6):1529-1533.

[5]Baraka, A., Kawkabani, N., Dabbous, A., et al., 2000. Lidocaine for prevention of reperfusion ventricular fibrillation after release of aortic cross-clamping. J. Cardiothor. Vas. An., 14(5):531-533.

[6]Baravelli, M., Cattaneo, P., Rossi, A., et al., 2010. Low-risk profile for malignant ventricular arrhythmias and sudden cardiac death after surgical ventricular reconstruction. Pacing Clin. Electrophysiol., 33(9):1054-1062.

[7]Chevalier, P., Timour, Q., Morel, E., et al., 2012. Chronic oral amiodarone but not dronedarone therapy increases ventricular defibrillation threshold during acute myocardial ischemia in a closed-chest animal model. J. Cardiovasc. Pharmacol., 59(6):523-528.

[8]Doherty, P.W., McLaughlin, P.R., Billingham, M., et al., 1979. Cardiac damage produced by direct current countershock applied to the heart. Am. J. Cardiol., 43(2):225-232.

[9]Dorian, P., Cass, D., Schwartz, B., et al., 2002. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N. Engl. J. Med., 347(12):955.

[10]Fiore, A.C., Naunheim, K.S., Taub, J., et al., 1990. Myocardial preservation using lidocaine blood cardioplegia. Ann. Thorac. Surg., 50(5):771-775.

[11]Furlan, A.D., Malmivaara, A., Chou, R., et al., 2015. 2015 updated method guideline for systematic reviews in the Cochrane Back and Neck Group. Spine, 40(21):1660-1673.

[12]Geissler, H.J., Schlensak, C., Sudkamp, M., et al., 2009. Heart valve surgery today: indications, operative technique, and selected aspects of postoperative care in acquired valvular heart disease. Dtsch. Arztebl. Int., 106(13):224-233.

[13]Ghavidel, A.A., Nabavi, S., Haghjoo, M., et al., 2013. Amiodarone versus lidocaine for the prevention of reperfusion ventricular fibrillation: a randomized clinical trial. ARYA Atheroscler., 1:343-349.

[14]Hippelainen, M.J., Tuppurainen, T.T., Huttunen, K.T., 1994. Reperfusion ventricular fibrillation and electric countershocks during coronary artery bypass operations-association with postoperative CK-MB release. J. Thorac. Cardiovasc. Surg., 28(2):73-78.

[15]Kirlangitis, J., Middaugh, R., Knight, R., et al., 1990. Comparison of bretylium and lidocaine in the prevention of ventricular fibrillation after aortic cross-clamp release in coronary artery bypass surgery. J. Cardiothorac. Anesth., 4(5):582-587.

[16]Komori, S., Li, B., Matsumura, K., et al., 1999. Antiarrhythmic effect of magnesium sulfate against occlusion-induced arrhythmias and reperfusion-induced arrhythmias in anesthetized rats. Mol. Cell Biochem., 199(1-2):201-208.

[17]Leeuwenburgh, B.P., Versteegh, M.I., Maas, J.J., et al., 2008. Should amiodarone or lidocaine be given to patients who arrest after cardiac surgery and fail to cardiovert from ventricular fibrillation? Interact. Cardiovasc. Thorac. Surg., 7(6):1148-1151.

[18]Levine, J.H., Massumi, A., Scheinman, M.M., et al., 1996. Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias intravenous amiodarone multicenter trial group. J. Am. Coll. Cardiol., 27(1):67-75.

[19]Liu, X.B., Jiang, J.B., Zhou, Q.J., et al., 2015. Evaluation of the safety and efficacy of transcatheter aortic valve implantation in patients with a severe stenotic bicuspid aortic valve in a Chinese population. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 16(3):208-214.

[20]Marathe, S.P., Talwar, S., 2015. Surgery for transposition of great arteries: a historical perspective. Ann. Pediatr. Cardiol., 8(2):122-128.

[21]Mauermann, W.J., Pulido, J.N., Barbara, D.W., et al., 2012. Amiodarone versus lidocaine and placebo for the prevention of ventricular fibrillation after aortic crossclamping: a randomized, double-blind, placebo-controlled trial. J. Thorac. Cardiovasc. Surg., 144(5):1229-1234.

[22]Mery, C.M., Kane, L.C., 2017. The ACGME fellowship in congenital cardiac surgery: the graduates’ perspective. Semin. Thorac. Cardiovasc. Surg. Pediatr. Card. Surg. Ann., 20:70-76.

[23]Moher, D., Liberati, A., Tetzlaff, J., et al., 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann. Intern. Med., 151(4):264-269.

[24]Nayeem Ul, H., Dar, A.M., Wani, M.L., et al., 2013. A comparative study on the effect of amiodarone and metaprolol for prevention of arrythmias after open heart surgery. Int. Cardiovasc. Res. J., 7(1):1-4.

[25]Onk, O.A., Erkut, B., 2015. Is the preoperative administration of amiodarone or metoprolol more effective in reducing atrial fibrillation: after coronary bypass surgery? Medicine (Baltimore), 94(41):e1576.

[26]Papakonstantinou, N.A., Baikoussis, N.G., Dedeilias, P., et al., 2017. Cardiac surgery or interventional cardiology? Why not both? Let’s go hybrid. J. Cardiol., 69(1):46-56.

[27]Patil, K.D., Halperin, H.R., Becker, L.B., 2015. Cardiac arrest: resuscitation and reperfusion. Circ. Res., 116(12):2041-2049.

[28]Petrovic, T., Adnet, F., Lapandry, C., 1998. Successful resuscitation of ventricular fibrillation after low-dose amiodarone. Ann. Emerg. Med., 32(4):518-519.

[29]Samantaray, A., Chandra, A., Panigrahi, S., 2010. Amiodarone for the prevention of reperfusion ventricular fibrillation. J. Cardiothorac. Vasc. Anesth., 24(2):239-243.

[30]Schluter, T., Baum, H., Plewan, A., et al., 2001. Effects of implantable cardioverter defibrillator implantation and shock application on biochemical markers of myocardial damage. Clin. Chem., 47(3):459-463.

[31]Shake, J.G., Pronovost, P.J., Whitman, G.J., 2013. Cardiac surgical ICU care: eliminating ‘preventable’ complications. J. Card. Surg., 28(4):406-413.

[32]Somberg, J.C., Bailin, S.J., Haffajee, C.I., et al., 2002. Intravenous lidocaine versus intravenous amiodarone (in a new aqueous formulation) for incessant ventricular tachycardia. Am. J. Cardiol., 90(8):853-859.

[33]Vaziri, M.T.M., Jouibar, R., Akhlagh, S.H.A., et al., 2010. The effect of lidocaine and magnesium sulfate on prevention of ventricular fibrillation in coronary artery bypass grafting surgery. Iran Red Crescent Med. J., 12(3):298-301.

[34]Verrier, E.D., Mack, M.J., 2015. Viewpoint: transitions in cardiac surgery and interventional cardiology team mates or rivals? Heart, 101(5):346-348.

[35]Wenger, T.L., Lederman, S., Starmer, C.F., et al., 1984. A method for quantitating antifibrillatory effects of drugs after coronary reperfusion in dogs: improved outcome with bretylium. Circulation, 69(1):142-148.

[36]Wu, L., Jin, Q., Zhang, N., et al., 2011. The effects of acute amiodarone on short-and long-duration ventricular defibrillation threshold in canines. J. Cardiovasc. Pharmacol., 58(4):432-438.

[37]Wyman, M.G., Wyman, R.M., Cannom, D.S., et al., 2004. Prevention of primary ventricular fibrillation in acute myocardial infarction with prophylactic lidocaine. Am. J. Cardiol., 94(5):545-551.

[38]Yamaguchi, H., Weil, M., Tang, W., et al., 2002. Myocardial dysfunction after electrical defibrillation. Resuscitation, 54(3):289-296.

[39]Yeh, S.T., Aune, S.E., Wilgus, T.A., et al., 2013. Hyperoxemic reperfusion after prolonged cardiac arrest in a rat cardiopulmonary bypass resuscitation model. Resuscitation, 84(1):114-120.

[40]Yilmaz, M., Aydin, U., Arslan, Z.I., et al., 2014. The effect of lidocaine and amiodarone on prevention of ventricular fibrillation in patients undergoing coronary artery bypass grafting. Heart Surg. Forum., 17(5):245-249.

[41]Zhan, H.T., Purcell, S.T., Bush, R.L., 2015. Preoperative optimization of the vascular surgery patient. Vasc. Health Risk Manag., 11:379-385.

[42]Zoerner, F., Semenas, E., 2014. Resuscitation with amiodarone increases survival after hemorrhage and ventricular fibrillation in pigs. J. Trauma Acute Care Surg., 76(6):1402-1408.

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