CLC number: R587.1
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2018-05-14
Cited: 0
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Xiao-xuan Guo, Yong Wang, Kai Wang, Bao-ping Ji, Feng Zhou. Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection[J]. Journal of Zhejiang University Science B, 2018, 19(7): 559-569.
@article{title="Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection",
author="Xiao-xuan Guo, Yong Wang, Kai Wang, Bao-ping Ji, Feng Zhou",
journal="Journal of Zhejiang University Science B",
volume="19",
number="7",
pages="559-569",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700254"
}
%0 Journal Article
%T Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection
%A Xiao-xuan Guo
%A Yong Wang
%A Kai Wang
%A Bao-ping Ji
%A Feng Zhou
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 7
%P 559-569
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700254
TY - JOUR
T1 - Stability of a type 2 diabetes rat model induced by high-fat diet feeding with low-dose streptozotocin injection
A1 - Xiao-xuan Guo
A1 - Yong Wang
A1 - Kai Wang
A1 - Bao-ping Ji
A1 - Feng Zhou
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 7
SP - 559
EP - 569
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700254
Abstract: Objective: The present study aims at determining the stability of a popular type 2 diabetes rat model induced by a high-fat diet combined with a low-dose streptozotocin injection. Methods: Wistar rats were fed with a high-fat diet for 8 weeks followed by a one-time injection of 25 or 35 mg/kg streptozotocin to induce type 2 diabetes. Then the diabetic rats were fed with regular diet/high-fat diet for 4 weeks. Changes in biochemical parameters were monitored during the 4 weeks. Results: All the rats developed more severe dyslipidemia and hepatic dysfunction after streptozotocin injection. The features of 35 mg/kg streptozotocin rats more resembled type 1 diabetes with decreased body weight and blood insulin. Rats with 25 mg/kg streptozotocin followed by normal diet feeding showed normalized blood glucose level and pancreatic structure, indicating that normal diet might help recovery from certain symptoms of type 2 diabetes. In comparison, diabetic rats fed with high-fat diet presented decreased but relatively stable blood glucose level, and this was significantly higher than that of the control group (P<0.05). Conclusions: This model easily recovers with normal diet feeding. A high-fat diet is suggested as the background diet in future pharmacological studies using this model.
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