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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.12 P.921-939

http://doi.org/10.1631/jzus.B2000423


Weathering the storm: COVID-19 infection in patients with hematological malignancies


Author(s):  Lin-qin Wang, Elaine Tan Su Yin, Guo-qing Wei, Yong-xian Hu, Arnon Nagler, He Huang

Affiliation(s):  Bone Marrow Transplantation Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   huyongxian2000@aliyun.com, Arnon.Nagler@sheba.health.gov.il, huanghe@zju.edu.cn

Key Words:  Coronavirus disease 2019 (COVID-19), Hematological malignancies, Immunosuppressive status, Management strategies, Treatment regimen


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Lin-qin Wang, Elaine Tan Su Yin, Guo-qing Wei, Yong-xian Hu, Arnon Nagler, He Huang. Weathering the storm: COVID-19 infection in patients with hematological malignancies[J]. Journal of Zhejiang University Science B, 2020, 21(12): 921-939.

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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000423"
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%A Lin-qin Wang
%A Elaine Tan Su Yin
%A Guo-qing Wei
%A Yong-xian Hu
%A Arnon Nagler
%A He Huang
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%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000423

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A1 - Lin-qin Wang
A1 - Elaine Tan Su Yin
A1 - Guo-qing Wei
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A1 - Arnon Nagler
A1 - He Huang
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000423


Abstract: 
The coronavirus disease 2019 (COVID-19) is an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within a matter of months, this highly contagious novel virus has led to a global outbreak and is still spreading rapidly across continents. In patients with COVID-19, underlying chronic diseases and comorbidities are associated with dismal treatment outcomes. Owing to their immunosuppressive status, patients with hematological malignancies (HMs) are at an increased risk of infection and have a worse prognosis than patients without HMs. Accordingly, intensive attention should be paid to this cohort. In this review, we summarize and analyze specific clinical manifestations for patients with coexisting COVID-19 and HMs. Furthermore, we briefly describe customized management strategies and interventions for this susceptible cohort. This review is intended to guide clinical practice.

应对恶性血液肿瘤在新型冠状病毒肺炎疫情中的挑战

概要:新型冠状病毒肺炎(COVID-19)是一种由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新型传染病.SARS-CoV-2具有极强的传染性,因此在引发流行病后又使其迅速升级为全球大流行,至今仍在部分国家迅速传播.在COVID-19的感染者中,存在肿瘤等慢性病或伴有相关合并症的患者预后往往较差.同时,由于恶性血液肿瘤患者长期处于免疫抑制状态,往往感染风险更高且预后更差,所以十分值得我们关注.这篇综述归纳并分析了恶性血液肿瘤患者合并COVID-19后的临床表现.此外,归纳了疫情期间恶性肿瘤的管理策略和感染后的综合干预措施,旨在为临床提供指导.
关键词:新型冠状病毒肺炎(COVID-19);恶性血液肿瘤;免疫抑制;管理策略;治疗方案

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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