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On-line Access: 2022-11-15

Received: 2022-02-07

Revision Accepted: 2022-06-12

Crosschecked: 2022-11-16

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Yusheng SHU




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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.11 P.899-914


Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study

Author(s):  Cunjin WANG, Yong LI, Yuchen PAN, Luojing ZHOU, Xi ZHANG, Yan WEI, Fang GUO, Yusheng SHU, Ju GAO

Affiliation(s):  Department of Anesthesiology, Northern Jiangsu People’s Hospital, Yangzhou 225001, China; more

Corresponding email(s):   shuyusheng65@163.com, gaoju_003@163.com

Key Words:  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Delta variant, Vaccine, Hospitalization, Immune response

Cunjin WANG, Yong LI, Yuchen PAN, Luojing ZHOU, Xi ZHANG, Yan WEI, Fang GUO, Yusheng SHU, Ju GAO. Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study[J]. Journal of Zhejiang University Science B, 2022, 23(11): 899-914.

@article{title="Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study",
author="Cunjin WANG, Yong LI, Yuchen PAN, Luojing ZHOU, Xi ZHANG, Yan WEI, Fang GUO, Yusheng SHU, Ju GAO",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study
%A Cunjin WANG
%A Yong LI
%A Yuchen PAN
%A Luojing ZHOU
%A Yan WEI
%A Fang GUO
%A Yusheng SHU
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 11
%P 899-914
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200054

T1 - Clinical and immune response characteristics among vaccinated persons infected with SARS-CoV-2 delta variant: a retrospective study
A1 - Cunjin WANG
A1 - Yong LI
A1 - Yuchen PAN
A1 - Luojing ZHOU
A1 - Yan WEI
A1 - Fang GUO
A1 - Yusheng SHU
A1 - Ju GAO
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 11
SP - 899
EP - 914
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200054

ObjectiveThis study aimed to observe the clinical and immune response characteristics of vaccinated persons infected with the delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Yangzhou, China.
MethodsWe extracted the medical data of 129 patients with delta-variant infection who were admitted to Northern Jiangsu People’s Hospital (Yangzhou, China) between August and September, 2021. The patients were grouped according to the number of vaccine doses received into an unvaccinated group: a one-dose group and a two-dose group. The vaccine used was SARS-CoV-2-inactivated vaccine developed by Sinovac. We retrospectively analyzed the patients’ epidemiological, clinical, laboratory, and imaging data.
ResultsAlmost all patients with delta-variant infection in Yangzhou were elderly, and patients with severe/critical illness were over 70 years of age. The rates of severe/critical illness (P=0.006), fever (P=0.025), and dyspnea (P=0.045) were lower in the two-dose group than in the unvaccinated group. Compared to the unvaccinated group, the two-dose group showed significantly higher lymphocyte counts and significantly lower levels of C-reactive protein (CRP), interleukin-6 (IL-6), and D-dimer during hospitalization and a significantly higher positive rate of immunoglobulin G (IgG) antibodies at admission (all P<0.05). The cumulative probabilities of hospital discharge and negative virus conversion were also higher in the two-dose group than in the unvaccinated group (P<0.05).
ConclusionsTwo doses of the SARS-CoV-2-inactivated vaccine were highly effective at limiting symptomatic disease and reducing immune response, while a single dose did not seem to be effective.

新冠疫苗对SARS-CoV-2 Delta感染者临床症状和免疫应答反应的影响:一项回顾性研究



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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