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On-line Access: 2023-04-10

Received: 2022-10-17

Revision Accepted: 2023-01-12

Crosschecked: 2023-04-14

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 ORCID:

Heng ZHANG

https://orcid.org/0000-0002-9396-7055

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.4 P.301-311

http://doi.org/10.1631/jzus.B2200519


Iron accumulation and its impact on osteoporotic fractures in postmenopausal women


Author(s):  Hui CAI, Huimei ZHANG, Weiting HE, Heng ZHANG

Affiliation(s):  Department of Pharmacy, the First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu 233004, China; more

Corresponding email(s):   bygkzhangheng@163.com

Key Words:  Iron accumulation, Postmenopausal osteoporosis, Bone metabolism, Osteoporotic fracture


Hui CAI, Huimei ZHANG, Weiting HE, Heng ZHANG. Iron accumulation and its impact on osteoporotic fractures in postmenopausal women[J]. Journal of Zhejiang University Science B, 2023, 24(4): 301-311.

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Abstract: 
postmenopausal osteoporosis is a kind of degenerative disease, also described as “invisible killer.” Estrogen is generally considered as the key hormone for women to maintain bone mineral content during their lives. iron accumulation refers to a state of human serum ferritin that is higher than the normal value but less than 1000 μg/L. It has been found that iron accumulation and osteoporosis could occur simultaneously with the decrease in estrogen level after menopause. In recent years, many studies indicated that iron accumulation plays a vital role in postmenopausal osteoporosis, and a significant correlation has been found between iron accumulation and fragility fractures. In this review, we summarize and analyze the relevant literature including randomized controlled trials, systematic reviews, and meta-analyses between January 1996 and July 2022. We investigate the mechanism of the effect of iron accumulation on bone metabolism and discuss the relationship of iron accumulation, osteoporosis, and postmenopausal fragility fractures, as well as the main clinical treatment strategies. We conclude that it is necessary to pay attention to the phenomenon of iron accumulation in postmenopausal women with osteoporosis and explore the in-depth mechanism of abnormal bone metabolism caused by iron accumulation, in order to facilitate the discovery of effective therapeutic targets for postmenopausal osteoporosis.

铁蓄积及其对女性绝经后骨质疏松性骨折的影响

蔡慧1,2,张慧妹3,何玮廷3,张衡4,5
1蚌埠医学院第一附属医院药剂科,中国蚌埠市,233004
2蚌埠医学院药学院,中国蚌埠市,233030
3蚌埠医学院临床医学院,中国蚌埠市,233030
4蚌埠医学院第一附属医院骨科,安徽省组织移植重点实验室,蚌埠医学院,中国蚌埠市,233004
5南京大学医学院金陵医院骨科,中国南京市,210002
概要:绝经后骨质疏松症是一种发生于骨骼的退行性疾病,号称"隐形杀手"。雌激素是女性一生中维持骨矿物质含量的关键激素。铁蓄积是指人血清铁蛋白高于正常值但低于1000 µg/L的状态。研究发现,绝经后随着雌激素水平的降低,铁蓄积和骨质疏松症可同时发生。近年来,很多研究表明铁蓄积在绝经后骨质疏松症发生中起着至关重要的作用,且铁蓄积与骨质疏松性骨折也有显著的相关性。在本文中,我们对1996年1月至2022年7月期间的随机对照试验、系统综述和荟萃分析等相关文献进行了总结和分析,探讨铁蓄积对骨代谢影响的机制,阐明铁蓄积与骨质疏松、绝经后脆性骨折的关系及临床主要治疗策略。我们总结认为,有必要关注女性绝经后骨质疏松铁蓄积现象。深入探讨铁蓄积引起骨代谢异常的机制,有助于发现绝经后骨质疏松有效的治疗靶点。

关键词:铁蓄积;绝经后骨质疏松;骨代谢;骨质疏松性骨折

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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