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On-line Access: 2023-06-13

Received: 2023-01-18

Revision Accepted: 2023-03-03

Crosschecked: 2023-07-21

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Citations:  Bibtex RefMan EndNote GB/T7714


Yuan-qiang Lu


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.6 P.539-542


Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection

Author(s):  Zhaodi WANG, Xuan LU, Yunmei YANG, Yuanqiang LU

Affiliation(s):  Department of Geriatric and Emergency Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   luyuanqiang@zju.edu.cn

Key Words:  Epstein-Barr virus (EBV), Inflammatory granuloma, Metagenomic next-generation sequencing

Zhaodi WANG, Xuan LU, Yunmei YANG, Yuanqiang LU. Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection[J]. Journal of Zhejiang University Science B, 2023, 24(6): 539-542.

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T1 - Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection
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epstein-Barr virus (EBV), a double-stranded DNA virus with an envelope, is a ubiquitous pathogen that is prevalent in humans, although most people who contract it do not develop symptoms (Kerr, 2019). While the primary cells EBV attacks are epithelial cells and B lymphocytes, its target range expands to a variety of cell types in immunodeficient hosts. Serological change occurs in 90% of infected patients. Therefore, immunoglobulin M (IgM) and IgG, serologically reactive to viral capsid antigens, are reliable biomarkers for the detection of acute and chronic EBV infections (Cohen, 2000). Symptoms of EBV infection vary according to age and immune status. Young patients with primary infection may present with infectious mononucleosis; there is a typical triad of symptoms including fever, angina, and lymphadenectasis (Houen and Trier, 2021). In immunocompromised patients, response after EBV infection may be atypical, with unexplained fever. The nucleic acid of EBV can be detected to confirm whether high-risk patients are infected (Smets et al., 2000). EBV is also associated with the occurrence of certain tumors (such as lymphoma and nasopharyngeal carcinoma) because it transforms host cells (Shannon-Lowe et al., 2017; Tsao et al., 2017).

气管炎性肉芽肿: 1例罕见的EB病毒感染患者



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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