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On-line Access: 2024-04-07

Received: 2023-06-28

Revision Accepted: 2023-09-03

Crosschecked: 2024-04-07

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Citations:  Bibtex RefMan EndNote GB/T7714


Yuan-qiang Lu


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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.4 P.354-358


Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning

Author(s):  Ping WANG, Congying SONG, Xuan LU, Yuanqiang LU

Affiliation(s):  Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou310003,China; more

Corresponding email(s):   luyuanqiang@zju.edu.cn

Key Words:  Glufosinate-ammonium, Seizure, Herbicide intoxication, Head CT

Ping WANG, Congying SONG, Xuan LU, Yuanqiang LU. Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning[J]. Journal of Zhejiang University Science B, 2024, 25(4): 354-358.

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T1 - Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning
A1 - Ping WANG
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DOI - 10.1631/jzus.B2300469

glufosinate-ammonium herbicides are the most widely used broad-spectrum, non-selective herbicides in the world. glufosinate-ammonium is a structural analogue of glutamate (Glu) which can irreversibly inhibit the activity of glutamine synthetase (GS) and Glu decarboxylase in plants, thereby blocking the synthesis of glutamine (Gln) from Glu and ammonia (Hoerlein, 1994). This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia. In humans, the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity (Watanabe and Sano, 1998). Currently, there are no antidotes for glufosinate-ammonium herbicide poisoning, and thus supportive care is the key treatment.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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