Full Text:   <156>

CLC number: 

On-line Access: 2023-12-31

Received: 2023-10-06

Revision Accepted: 2023-12-17

Crosschecked: 0000-00-00

Cited: 0

Clicked: 236

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300691


Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis


Author(s):  Hai ZOU, Mengyu ZHANG, Xue YANG, Huafeng SHOU, Zhenglin CHEN, Quanfeng ZHU, Ting LUO, Xiaozhou MOU, Xiaoyi CHEN

Affiliation(s):  Department of Critical Care Medicine, Fudan University Shanghai Cancer Center, Shanghai 200032, China; more

Corresponding email(s):   mouxz@zju.edu.cn, chenxiaoyi@hmu.edu.cn

Key Words:  Cynaroside, Doxorubicin, Pyroptosis, Cardiotoxicity, Oxidative stress


Hai ZOU, Mengyu ZHANG, Xue YANG, Huafeng SHOU, Zhenglin CHEN, Quanfeng ZHU, Ting LUO, Xiaozhou MOU, Xiaoyi CHEN. Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

@article{title="Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis",
author="Hai ZOU, Mengyu ZHANG, Xue YANG, Huafeng SHOU, Zhenglin CHEN, Quanfeng ZHU, Ting LUO, Xiaozhou MOU, Xiaoyi CHEN",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300691"
}

%0 Journal Article
%T Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis
%A Hai ZOU
%A Mengyu ZHANG
%A Xue YANG
%A Huafeng SHOU
%A Zhenglin CHEN
%A Quanfeng ZHU
%A Ting LUO
%A Xiaozhou MOU
%A Xiaoyi CHEN
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300691

TY - JOUR
T1 - Cynaroside regulates the AMPK/SIRT3/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis
A1 - Hai ZOU
A1 - Mengyu ZHANG
A1 - Xue YANG
A1 - Huafeng SHOU
A1 - Zhenglin CHEN
A1 - Quanfeng ZHU
A1 - Ting LUO
A1 - Xiaozhou MOU
A1 - Xiaoyi CHEN
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300691


Abstract: 
doxorubicin (DOX) is a commonly administered chemotherapy drug for treating hematological malignancies and solid tumors; however, its clinical application is limited by significant cardiotoxicity. cynaroside (Cyn) is a flavonoid glycoside distributed in honeysuckle, with confirmed potential biological functions in regulating inflammation, pyroptosis and oxidative stress. Herein, the effects of Cyn were evaluated in a DOX-induced cardiotoxicity (DIC) mice model, which was established by intraperitoneal injections of DOX (5 mg/kg) once a week for three weeks. The mice in the treatment group received dexrazoxane, MCC950 and Cyn every two days. Blood biochemistry, histopathology, immunohistochemistry, RT-qPCR, and Western blotting were conducted to investigate the cardioprotective effects and potential mechanisms of Cyn treatment. The results demonstrated the significant benefits of Cyn treatment in mitigating DIC; it could effectively alleviate oxidative stress to a certain extent, maintain the equilibrium of cell apoptosis, and enhance the cardiac function of mice. These effects were realized via regulating the transcription levels of pyroptosis-related genes, such as NLRP3, Caspase-1 and GSDMD. Mechanistically, for DOX-induced myocardial injury, Cyn could significantly modulate the expression of pivotal genes, including AMPK, PGC-1α, Sirt3, and Nrf2, which we attribute to the mediation of AMPK/Sirt3/Nrf2 pathway, which plays a central role in countering doxorubicin-induced cardiomyocyte injury. In conclusion, the present study confirms the therapeutic potential of Cyn in DIC by regulating the AMPK/SIRT3/Nrf2 pathway.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE