Affiliation(s):
State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-sen University, Guangzhou 510006, China;
moreAffiliation(s): State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-sen University, Guangzhou 510006, China; School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China;Pazhou Lab, Guangzhou 510330, China;The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510006, China;;
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Abstract: Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo. Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation, and the presence of reactive oxygen species (ROS) due to inflammation may affect glucose detection. Microneedle technology is less invasive, yet microneedle adhesion with skin tissue is limited. In this work, we developed a microarrow sensor array (MASA), which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H2O2 (representative of ROS) in interstitial fluid in vivo. The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional (3D) microneedle array. Due to the arrow tip mechanically interlocking with the tissue, the microarrow array could better adhere to the skin surface after penetration into skin. The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H2O2 concentrations, with the detection of H2O2 providing a valuable reference for assessing the inflammation state. Finally, the MASA was integrated into a monitoring system using custom circuitry. This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.
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