JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE

Accepted manuscript available online (unedited version)

The prospects for bioprinting tumor models: recent advances in their applications

Author(s): Changru Zhang, Xiaoqin Qiu, Yu Dai, Weiqing Kong, Yihao Liu, Haoyi Niu, Chengwei Wang, Xuelian Mi, Hui Wang, Ya Ren, Han Yang, Kerong Dai, Jinwu Wang
Affiliation(s): School of Rehabilitation Medicine, Weifang Medical University, Shandong 261041, China;Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Institute of Rehabilitation Medicine, School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China; Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; Chengdu Fifth People’s Hospital, Chengdu 611130, China; Department of Pancreatic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.; Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China; College of Medicine, Southwest Jiaotong University, Chengdu 610036, China; Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China;
Corresponding email(s): wangjw-team@shsmu.edu.cn, krdai@163.com, yanghan0609@sjtu.edu.cn
Key Words: Bioprinting;Tissue Engineering;Tumor Organoid

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Changru Zhang, Xiaoqin Qiu, Yu Dai, Weiqing Kong, Yihao Liu, Haoyi Niu, Chengwei Wang, Xuelian Mi, Hui Wang, Ya Ren, Han Yang, Kerong Dai, Jinwu Wang. The prospects for bioprinting tumor models: recent advances in their applications[J]. Journal of Zhejiang University Science ,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1007/s42242-022-00223-X

@article{title="The prospects for bioprinting tumor models: recent advances in their applications",
author="Changru Zhang, Xiaoqin Qiu, Yu Dai, Weiqing Kong, Yihao Liu, Haoyi Niu, Chengwei Wang, Xuelian Mi, Hui Wang, Ya Ren, Han Yang, Kerong Dai, Jinwu Wang",
journal="Journal of Zhejiang University Science ",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1007/s42242-022-00223-X"
}

%0 Journal Article
%T The prospects for bioprinting tumor models: recent advances in their applications
%A Changru Zhang
%A Xiaoqin Qiu
%A Yu Dai
%A Weiqing Kong
%A Yihao Liu
%A Haoyi Niu
%A Chengwei Wang
%A Xuelian Mi
%A Hui Wang
%A Ya Ren
%A Han Yang
%A Kerong Dai
%A Jinwu Wang
%J Journal of Zhejiang University SCIENCE
%P
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%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1007/s42242-022-00223-X"

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T1 - The prospects for bioprinting tumor models: recent advances in their applications
A1 - Changru Zhang
A1 - Xiaoqin Qiu
A1 - Yu Dai
A1 - Weiqing Kong
A1 - Yihao Liu
A1 - Haoyi Niu
A1 - Chengwei Wang
A1 - Xuelian Mi
A1 - Hui Wang
A1 - Ya Ren
A1 - Han Yang
A1 - Kerong Dai
A1 - Jinwu Wang
J0 - Journal of Zhejiang University Science
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EP -
%@ 2095-9184
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1007/s42242-022-00223-X"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Three-dimensional (3D) tumor models prepared from patient-derived cells have been reported to imitate some of the biological development processes of in situ tumors in vitro. These 3D tumor models share several important characteristics with their in vivo tumor counterparts. Accordingly, their applications in tumor modeling, drug screening, and precision-targeted treatment are promising. However, the establishment of tumor models is subject to several challenges, including advancements in scale size, repeatability, structural precision in time and space, vascularization, and the tumor microenvironment. Recently, bioprinting technologies enabling the editorial arrangement of cells, factors, and materials have improved the simulation of tumor models in vitro. Among the 3D bioprinted tumor models, the organoid model has been widely appreciated for its advantages of maintaining high heterogeneity and capacity for simulating the developmental process of tumor tissues. In this review, we outline approaches and potential prospects for tumor model bioprinting and discuss the existing bioprinting technologies and bioinks in tumor model construction. The multidisciplinary combination of tumor pathology, molecular biology, material science, and additive manufacturing will help overcome the barriers to tumor model construction by allowing consideration of the structural and functional characteristics of in vitro models and promoting the development of heterogeneous tumor precision therapies.

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