Affiliation(s):
State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, Sun Yat-sen University, Guangzhou 510006, China;
School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China;Pazhou Lab, Guangzhou 510330, China;The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510006, China
Xinshuo Huang,Baoming Liang,Shantao Zheng,Feifei Wu,Mengyi He,Shuang Huang,Jingbo Yang,Qiangqiang Ouyang,Fanmao Liu,Jing Liu,Hui-jiuan Chen, Xi Xie. Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species[J]. Journal of Zhejiang University Science ,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1007/s42242-023-00031-X
@article{title="Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species", author="Xinshuo Huang,Baoming Liang,Shantao Zheng,Feifei Wu,Mengyi He,Shuang Huang,Jingbo Yang,Qiangqiang Ouyang,Fanmao Liu,Jing Liu,Hui-jiuan Chen, Xi Xie", journal="Journal of Zhejiang University Science ", year="in press", publisher="Zhejiang University Press & Springer", doi="https://doi.org/10.1007/s42242-023-00031-X" }
%0 Journal Article %T Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species %A Xinshuo Huang %A Baoming Liang %A Shantao Zheng %A Feifei Wu %A Mengyi He %A Shuang Huang %A Jingbo Yang %A Qiangqiang Ouyang %A Fanmao Liu %A Jing Liu %A Hui-jiuan Chen %A Xi Xie %J Journal of Zhejiang University SCIENCE %P %@ 2095-9184 %D in press %I Zhejiang University Press & Springer doi="https://doi.org/10.1007/s42242-023-00031-X"
TY - JOUR T1 - Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species A1 - Xinshuo Huang A1 - Baoming Liang A1 - Shantao Zheng A1 - Feifei Wu A1 - Mengyi He A1 - Shuang Huang A1 - Jingbo Yang A1 - Qiangqiang Ouyang A1 - Fanmao Liu A1 - Jing Liu A1 - Hui-jiuan Chen A1 - Xi Xie J0 - Journal of Zhejiang University Science SP - EP - %@ 2095-9184 Y1 - in press PB - Zhejiang University Press & Springer ER - doi="https://doi.org/10.1007/s42242-023-00031-X"
Abstract: Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo. Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation, and the presence of reactive oxygen species (ROS) due to inflammation may affect glucose detection. Microneedle technology is less invasive, yet microneedle adhesion with skin tissue is limited. In this work, we developed a microarrow sensor array (MASA), which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H2O2 (representative of ROS) in interstitial fluid in vivo. The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional (3D) microneedle array. Due to the arrow tip mechanically interlocking with the tissue, the microarrow array could better adhere to the skin surface after penetration into skin. The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H2O2 concentrations, with the detection of H2O2 providing a valuable reference for assessing the inflammation state. Finally, the MASA was integrated into a monitoring system using custom circuitry. This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.
Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
Reference
Open peer comments: Debate/Discuss/Question/Opinion
Open peer comments: Debate/Discuss/Question/Opinion
<1>