Journal of Zhejiang University

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Microneedles for non-transdermal drug delivery: design strategies and current applications

Author(s): Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu
Affiliation(s): Department of Pharmacy, The Fourth Central Hospital of Baoding City, Baoding 072350, China; Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China; Department of Medical Business, The Fourth Central Hospital of Baoding City, Baoding 072350, China
Corresponding email(s): hestxrmyygrglk@163.com, nxf@buaa.edu.cn
Key Words: Microneedles (MNs) · Biocompatible materials · Non-transdermal drug delivery · Controlled release

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Jinhong Xu, Xiangyi Liao, Danli Chen, Xiuzhuo Jia, Xufeng Niu. Microneedles for non-transdermal drug delivery: design strategies and current applications[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/bdm2300352

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doi="https://doi.org/10.1631/bdm2300352"
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Microneedles (MNs) are an innovative and viable option for drug delivery that offer the distinct advantages of minimal inva‐ siveness, painlessness, stable drug loading, efficient drug permeation, and biocompatibility. MNs were first used to penetrate the skin surface and facilitate transcutaneous drug delivery with great success. Recent applications of MNs have extended to non-transdermal drug delivery, specifically, to various tissues and organs. This review captures the fabrication methods for MNs, discusses advanced design strategies for achieving controlled drug release, and summarizes current MN applications in delivering multiple therapeutic agents to the cardiovascular, digestive (e.g., oral cavity), reproductive, and central nervous systems. The findings in this review would contribute toward the improved designs of MN systems that can be modified ac‐ cording to purpose, including material selection, structural design, choice of fabrication methods, and tissue considerations, to determine the optimal therapeutic regimen for the target treatment area.

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On-line Access: 2025-03-15

Received: 2023-12-07

Revision Accepted: 2024-10-08

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Citations: Bibtex RefMan EndNote GB/T7714

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