JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Author(s): Yue-qiu Luo^1;2;3, Xiao-xing Wu¹, Zong-xin Ling^1;3, Yi-wen Cheng^1;3, Li Yuan^1;3, Charlie Xiang^1;3
Affiliation(s): 1. State Key Laboratory for Diagnosis and Treatment of Infectious Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China;2. Department of Biochemistry and Molecular Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China;3. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China
Corresponding email(s): cxiang@zju.edu.cn
Key Words: Vitamin D, Fibrosis, Hepatitis C virus, Meta-analysis

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Yue-qiu Luo, Xiao-xing Wu, Zong-xin Ling, Yi-wen Cheng, Li Yuan, Charlie Xiang. Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B1400073

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author="Yue-qiu Luo, Xiao-xing Wu, Zong-xin Ling, Yi-wen Cheng, Li Yuan, Charlie Xiang",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B1400073"
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%0 Journal Article
%T Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis
%A Yue-qiu Luo
%A Xiao-xing Wu
%A Zong-xin Ling
%A Yi-wen Cheng
%A Li Yuan
%A Charlie Xiang
%J Journal of Zhejiang University SCIENCE B
%P 900-906
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B1400073"

TY - JOUR
T1 - Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis
A1 - Yue-qiu Luo
A1 - Xiao-xing Wu
A1 - Zong-xin Ling
A1 - Yi-wen Cheng
A1 - Li Yuan
A1 - Charlie Xiang
J0 - Journal of Zhejiang University Science B
SP - 900
EP - 906
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B1400073"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: To conduct a systematic review of group studies assessing the association of serum vitamin D status with the severity of liver fibrosis in chronic hepatitis C patients using meta-analysis. The relevant research literatures were identified by searching PubMed and EMBASE databases prior to October 2013 with no restrictions. We included group studies that reported odds ratio (OR) estimates with 95% confidence intervals (CIs) or a mean with standard deviation (SD) for the association between serum vitamin D status and the severity of liver fibrosis in chronic hepatitis C patients. Approximately 8321 participants from several countries were included in this analysis. Six studies on serum vitamin D status and the severity of liver fibrosis were included in this meta-analysis. ORs with 95% CIs were extracted from four studies and the pooled ORs were 0.866 (95% CI, 0.649 to 1.157). The means with SDs were extracted from three studies and the pooled means were −0.487 (95% CI, −0.659 to −0.315). There was statistically significant heterogeneity among the mean data extracted studies (P=0.029; I ²=71.8%) but not among the OR data extracted studies (P=0.061; I ²=55.6%). Finally, results from the mean data extracted studies suggest that lower serum vitamin D is a risk factor for the severity of liver fibrosis in chronic hepatitis C patients. However, there is no conclusive evidence on this association because of inconsistencies between the OR data extracted studies and the mean data extracted studies.

慢性丙型肝炎患者的血清维生素D与严重肝纤维化相关性研究：系统性的荟萃分析

研究目的：利用meta分析方法来探索慢性丙型肝炎患者低血清维生素D水平与严重肝纤维化相关性。
创新要点：丙型病毒性肝炎病人的低血清维生素D水平与严重肝纤维化并不一定有相关性。
研究方法：结合已发表的临床研究数据，采用荟萃分析方法，定量分析低血清维生素D水平与慢性丙型肝炎患者严重肝纤维化相关性（图2；表2）。
重要结论：此荟萃分析对于认识丙型肝炎病人低血清维生素D水平与肝纤维化严重程度的相关性有重要意义，对未来相关临床研究具有指导意义。
维生素D；纤维化；丙型病毒性肝炎；荟萃分析

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慢性丙型肝炎患者的血清维生素D与严重肝纤维化相关性研究：系统性的荟萃分析

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References