Abstract: Pheochromocytoma is a rare neuroendocrine tumor which derives from chromaffin cells of the adrenal gland or relevant to sympathetic nerves and ganglia. The clinical features of pheochromocytoma are various. Paroxysmal episodes of serious hypertension, headache, palpitation, and diaphoresis are the typical manifestations (Bravo, 2004). Hypotension shock, pulmonary edema, and acute coronary syndrome induced by pheochromocytoma are uncommon (Malindretos et al., 2008; Batisse-Lignier et al., 2015). In this study, we present a rare case of cystic pheochromocytoma causing recurrent hypotension shock, non-cardiogenic pulmonary edema, and acute coronary syndrome, and the possible mechanisms are discussed.

囊性嗜铬细胞瘤复发非心源性肺水肿和持续性低血压休克

[1]Batisse-Lignier, M., Pereira, B., Motreff, P., et al., 2015. Acute and chronic pheochromocytoma-induced cardiomyopathies: different prognoses? A systematic analytical review. Medicine (Baltimore), 94(50):e2198.

[2]Bravo, E.L., 2004. Pheochromocytoma: current perspectives in the pathogenesis, diagnosis, and management. Arq. Bras. Endocrinol. Metabol., 48(5):746-750.

[3]Dahia, P.L., 2006. Evolving concepts in pheochromocytoma and paraganglioma. Curr. Opin. Oncol., 18(1):1-8.

[4]Eschen, O., Frøbert, O., Jensen, V., et al., 2007. Pheochromocytoma, a rare cause of acute cardiogenic shock. Clin. Res. Cardiol., 96(4):232-235.

[5]Giavarini, A., Chedid, A., Bobrie, G., et al., 2013. Acute catecholamine cardiomyopathy in patients with phaeochromocytoma or functional paraganglioma. Heart, 99(19): 1438-1444.

[6]Grasselli, G., Foti, G., Patroniti, N., et al., 2008. Extracorporeal cardiopulmonary support for cardiogenic shock caused by pheochromocytoma: a case report and literature review. Anesthesiology, 108(5):959-962.

[7]Kopetschke, R., Slisko, M., Kilisli, A., et al., 2009. Frequent incidental discovery of phaeochromocytoma: data from a German cohort of 201 phaeochromocytoma. Eur. J. Endocrinol., 161(2):355-361.

[8]Li, S.J., Wang, T., Wang, L., et al., 2016. Ventricular tachycardia and resembling acute coronary syndrome during pheochromocytoma crisis: a case report. Medicine (Baltimore), 95(14):e3297.

[9]Malindretos, P.M., Sarafidis, P.A., Geropoulou, E.Z., et al., 2008. Sustained hypotension complicating an extra-adrenal pheochromocytoma. Am. J. Hypertens., 21(7): 840-842.

[10]Omura, M., Saito, J., Yamaguchi, K., et al., 2004. Prospective study on the prevalence of secondary hypertension among hypertensive patients visiting a general outpatient clinic in Japan. Hypertens. Res., 27(3):193-202.

[11]Park, M., Hryniewicz, K., Setaro, J.F., 2009. Pheochromocytoma presenting with myocardial infarction, cardiomyopathy, renal failure, pulmonary hemorrhage, and cyclic hypotension: case report and review of unusual presentations of pheochromocytoma. J. Clin. Hypertens. (Greenwich), 11(2):74-80.

[12]Prejbisz, A., Lenders, J.W., Eisenhofer, G., et al., 2011. Cardiovascular manifestations of phaeochromocytoma. J. Hypertens., 29(11):2049-2060.

[13]Sarveswaran, V., Kumar, S., Kumar, A., et al., 2015. A giant cystic pheochromocytoma mimicking liver abscess an unusual presentation—a case report. Clin. Case Rep., 3(1): 64-68.

[14]Schifferdecker, B., Kodali, D., Hausner, E., et al., 2005. Adrenergic shock—an overlooked clinical entity? Cardiol. Rev., 13(2):69-72.

[15]List of electronic supplementary materials

[16]Fig. S1 Contrast-enhanced computed tomography scan of chest