JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

HIV and paraquat poisoning: fighting fire with fire?

Author(s): Yuan-qiang Lu
Affiliation(s): Department of Emergency Medicine, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Corresponding email(s): luyuanqiang@zju.edu.cn
Key Words: Paraquat; Human immunodeficiency virus; Immunosuppressive therapy

Share this article to： More <<< Previous Paper \|

Yuan-qiang Lu. HIV and paraquat poisoning: fighting fire with fire?[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B1700567

@article{title="HIV and paraquat poisoning: fighting fire with fire?",
author="Yuan-qiang Lu",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B1700567"
}

%0 Journal Article
%T HIV and paraquat poisoning: fighting fire with fire?
%A Yuan-qiang Lu
%J Journal of Zhejiang University SCIENCE B
%P 168-170
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B1700567"

TY - JOUR
T1 - HIV and paraquat poisoning: fighting fire with fire?
A1 - Yuan-qiang Lu
J0 - Journal of Zhejiang University Science B
SP - 168
EP - 170
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B1700567"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Though the cases of HIV patients with paraquat (PQ) poisoning are rare, we still found the common features. These recovered HIV patients tended to result in much less lung injury, and had low CD4⁺ T lymphocyte levels due to HIV infection, which meant they were under the immunosuppressive condition during treatment. This may be conducive to relieve the acute inflammation and lung fibrosis induced by PQ. Thus, we consider the immunosuppressive therapy for PQ poisoning to be appropriate. However, the drugs used currently may be not optimal for toxic patient. As next step, we will add the CD4⁺ T lymphocyte-targeted immunosuppressive drug to treat PQ poisoning patients.

HIV和百草枯中毒:以毒攻毒?

概要:回顾性分析PubMed收录的仅有3例合并有HIV的急性百草枯中毒患者的救治经过及预后.探索急性百草枯中毒新的免疫治疗.提出采用CD4⁺ T淋巴细胞作为急性百草枯中毒的免疫治疗精准靶点,可能改善预后,但需要进一步研究和临床实践.

关键词组：百草枯;艾滋病病毒;免疫抑制治疗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Gunnell D, Eddleston M, Phillips MR, et al., 2007. The global distribution of fatal pesticide self-poisoning: systematic review. BMC Public Health, 7:357.

[2]Hügle T, 2011. Immunology of fibrotic lung disease: managing infections whilst preventing autoimmunity? J Inflamm Res, 4:21-27.

[3]Ragoucy-Sengler C, Pileire B, 1996. Survival after paraquat poisoning in a HIV positive patient. Hum Exp Toxicol, 15: 286-288.

[4]Shang AD, Lu YQ, 2015. A case report of severe paraquat poisoning in an HIV-positive patient: an unexpected outcome and inspiration. Medicine, 94:e587.

[5]Shao X, Li M, Luo C, et al., 2015. Effects of rapamycin against paraquat-induced pulmonary fibrosis in mice. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 16(1):52-61.

[6]Tsai JL, Chen CH, Wu MJ, et al., 2016. Paraquat poisoning in patients with HIV infection: a case report and literature review. Medicine, 95:e3350.

[7]Wang HR, Pan J, Shang AD, et al., 2017. Time-dependent haemoperfusion after acute paraquat poisoning. Sci Rep, 7(1):2239.

[8]Zhang Q, Wu WZ, Lu YQ, et al., 2012. Successful treatment of patients with paraquat intoxication: three case reports and review of the literature. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 13(5):413-418.

[9]Zhao XH, Jiang JK, Lu YQ, 2015. Evaluation of efficacy of resin hemoperfusion in patients with acute 2,4-dinitrophenol poisoning by dynamic monitoring of plasma toxin concentration. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 16(8):720-726.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

- Go to

HIV和百草枯中毒:以毒攻毒?

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference