JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation

Author(s): Liwen WANG, Huimei LIU, Lanfang LI
Affiliation(s): Institute of Pharmaceutical Pharmacology, School of Pharmacy, University of South China, Hengyang421001, China; more
Corresponding email(s): 2005001782@usc.edu.cn
Key Words: Synthetic autophagy receptors; autophagy; p62; Protein aggregates; Organelle

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Liwen WANG, Huimei LIU, Lanfang LI. Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300853

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author="Liwen WANG, Huimei LIU, Lanfang LI",
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year="in press",
publisher="Zhejiang University Press & Springer",
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}

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%A Liwen WANG
%A Huimei LIU
%A Lanfang LI
%J Journal of Zhejiang University SCIENCE B
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T1 - Autophagy receptor-inspired chimeras: a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
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A1 - Huimei LIU
A1 - Lanfang LI
J0 - Journal of Zhejiang University Science B
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Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300853"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Neurodegenerative diseases (NDDs), mainly including Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD), are sporadic and rare genetic disorders of the central nervous system. A key feature of these conditions is the slow accumulation of misfolded protein deposits in brain neurons, the excessive aggregation of which leads to neurotoxicity and further disorders of the nervous system.

自噬受体激发嵌合体：一种通过自噬降解促进蛋白质聚集体和细胞器去除的新方法

王丽雯¹，刘惠美²，李兰芳¹
¹南华大学药学院药物药理研究所，中国衡阳市， 421001
²南华大学衡阳医学院，中国衡阳市， 421001
摘要：神经退行性疾病作为中枢神经系统的遗传性疾病，其主要特征是错误折叠的蛋白质聚集体在大脑神经元中缓慢积累。虽然自噬在降解蛋白质聚集体中发挥着至关重要的作用，但目前尚无有效且广泛适用的方法来降解哺乳动物细胞中的蛋白质聚集体。最新研究表明，合成的自噬受体启发的靶向嵌合体（AceTAC）作为降解剂可将选择性自噬受体-p62的LC3相互作用区（LIR）结构域与抗体结合，AceTAC降解剂可选择性靶向分解不同的蛋白质聚集体（例如mHTT、TDP-43和Tau）。此外，这些降解剂可靶向包括线粒体、过氧化物酶体和内质网在内的细胞器。综上，基于自噬的靶向降解剂AceTAC可作为一种有效治疗神经退行性疾病的新方法。

关键词组：合成自噬受体；自噬；p62；蛋白质聚集：细胞器

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自噬受体激发嵌合体：一种通过自噬降解促进蛋白质聚集体和细胞器去除的新方法

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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