JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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Role of the immune microenvironment in bone regeneration and progress in immune-modulating bone nanobiomaterials

Author(s): Rongan LI^1, ², Jiakang YANG^1, ², Wenjun DUAN^1, ², Kexin YANG^1, ², Katong LO^1, ², Qianming CHEN^1, ², Baixiang WANG^1, ²
Affiliation(s): ¹Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China; more
Corresponding email(s): wangbaixiang@zju.edu.cn, qmchen@zju.edu.cn
Key Words: Immune Microenvironment; Bone Defect; Bone Regeneration; Immunomodulation; Bone Nanobiomaterial

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Rongan LI^1,², Jiakang YANG^1,², Wenjun DUAN^1,², Kexin YANG^1,², Katong LO^1,², Qianming CHEN^1,², Baixiang WANG^1,². Role of the immune microenvironment in bone regeneration and progress in immune-modulating bone nanobiomaterials[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400472

@article{title="Role of the immune microenvironment in bone regeneration and progress in immune-modulating bone nanobiomaterials",
author="Rongan LI^1,², Jiakang YANG^1,², Wenjun DUAN^1,², Kexin YANG^1,², Katong LO^1,², Qianming CHEN^1,², Baixiang WANG^1,²",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400472"
}

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%A Baixiang WANG^1
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Inflammation is a key physiological process in the regeneration of bone tissue following injury. The acute inflammatory response, along with the timely resolution of inflammation, is essential for effective bone tissue repair. Exacerbation of either acute or chronic inflammation can lead to impaired bone regeneration, which is closely associated with interactions between immune cells and bone-related cells, as well as the regulatory roles of various inflammatory cytokines. In this review, we discuss the role of the immune microenvironment in bone regeneration and the negative impact of dysregulated inflammation on bone regeneration, and highlight on the need for timely elimination of inflammation. Additionally, the application of nanobiomaterials with immunomodulatory function in the treatment of inflammatory bone defects is discussed to clarify its current challenges and the future direction of its development.

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