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On-line Access: 2025-05-23

Received: 2025-03-11

Revision Accepted: 2025-05-01

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Journal of Zhejiang University SCIENCE B

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Tackling iron deficiency: the multifunctional benefits of biopolysaccharide-iron(III) complexes from traditional Chinese medicinal plants


Author(s):  Wenyang ZHAO1, 2, Chun-Wai MAI3, Kai Bin LIEW4, Siew-Keah LEE5, Wei DU6, Li CHEN7, Gabriel Akyirem AKOWUAH8, Yik-Ling CHEW1

Affiliation(s):  1Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia; more

Corresponding email(s):  chew.yikling@gmail.com

Key Words:  Traditional Chinese Medicine; Polysaccharides; Iron complex; Iron deficiency anaemia; Drug delivery


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Wenyang ZHAO1,2, Chun-Wai MAI3, Kai Bin LIEW4, Siew-Keah LEE5, Wei DU6, Li CHEN7, Gabriel Akyirem AKOWUAH8, Yik-Ling CHEW1. Tackling iron deficiency: the multifunctional benefits of biopolysaccharide-iron(III) complexes from traditional Chinese medicinal plants[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500114

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author="Wenyang ZHAO1,2, Chun-Wai MAI3, Kai Bin LIEW4, Siew-Keah LEE5, Wei DU6, Li CHEN7, Gabriel Akyirem AKOWUAH8, Yik-Ling CHEW1",
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A1 - Kai Bin LIEW4
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A1 - Wei DU6
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A1 - Yik-Ling CHEW1
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doi="https://doi.org/10.1631/jzus.B2500114"


Abstract: Traditional Chinese Medicinal (TCM) plants are known to contain bioactive ingredients, including beneficial biopolysaccharides that may also serve as excipients in drug formulation and delivery. Some of these biopolysaccharides also exhibit a wide range of biological activities. Biopolysaccharides have also been used in the development of biopolysaccharide-iron complexes that are characterized by high iron content, low gastrointestinal irritation and enhanced bioavailability, helping to overcome the limitations of conventional iron supplements. This review focuses on the unique properties of TCM-derived biopolysaccharides in addressing these limitations and highlights their bioavailability and therapeutic potential, including their roles in iron release and delivery, gastroprotective effects, blood sugar regulation, and antioxidant activity, as demonstrated in in vitro and in vivo experiments and clinical trials. The adverse reactions, safety profile and structure–activity relationship of biopolysaccharide-iron complexes in antioxidant activities are also thoroughly discussed. Supplementation with these next-generation iron complexes may represent a promising strategy for the treatment of iron deficiency anaemia and the promotion of overall human health and well-being.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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