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On-line Access: 2025-08-25
Received: 2025-03-17
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Yiyan YANG, Jue ZHOU. Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500127 @article{title="Effects of Citrus on oxidative stress and lipid metabolism modulation: its potential for improving female reproductive health", %0 Journal Article TY - JOUR
柑橘对氧化应激和脂质代谢调节的影响及其改善女性生殖健康的潜力浙江工商大学食品与生物工程学院,中国杭州市,310018 摘要:柑橘在国际上拥有悠久的食用历史,广泛被用作健康食品。柑橘及其活性成分对氧化应激和脂质代谢具有显著的调节作用,这些因素与女性生殖健康密切相关。研究表明,柑橘来源的化合物可能通过激活Nrf2和SIRT1等信号通路缓解氧化应激,并通过激活包括PPARα在内的信号通路改善脂质代谢。本文综述了柑橘对氧化应激和脂质代谢的影响,旨在为促进女性生殖健康提供新思路。然而,仍需进一步的研究明确其作用机制,且柑橘活性成分的临床治疗潜力仍有待验证。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
Reference[1]Abo-ZaidOAR, MoawedFSM, IsmailES, et al., 2023. β-Sitosterol attenuates high-fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway. BMC Pharmacol Toxicol, 24:31. ![]() [2]AgarwalA, GuptaS, SharmaRK, 2005. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol, 3:28. ![]() [3]AlamF, MohammadinK, ShafiqueZ, et al., 2022. Citrus flavonoids as potential therapeutic agents: a review. Phytother Res, 36(4):1417-1441. ![]() [4]AlamMA, SubhanN, RahmanMM, et al., 2014. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr, 5(4):404-417. ![]() [5]AlimohammadiM, MohammadRN, RahimiA, et al., 2022. The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical evidence. Inflamm Res, 71(10-11):1127-1142. ![]() [6]AminiL, ChekiniR, NateghiMR, et al., 2021. The effect of combined vitamin C and vitamin E supplementation on oxidative stress markers in women with endometriosis: a randomized, triple-blind placebo-controlled clinical trial. Pain Res Manag, 2021:5529741. ![]() [7]AnandakumarP, KamarajS, VanithaMK, 2021. D-Limonene: a multifunctional compound with potent therapeutic effects. J Food Biochem, 45:e13566. ![]() [8]AnnunziataF, PinnaC, DallavalleS, et al., 2020. An overview of coumarin as a versatile and readily accessible scaffold with broad-ranging biological activities. Int J Mol Sci, 21(13):4618. ![]() [9]AshrafizadehM, AhmadiZ, MohammadinejadR, et al., 2020. Tangeretin: a mechanistic review of its pharmacological and therapeutic effects. J Basic Clin Physiol Pharmacol, 31(4):20190191. ![]() [10]BedaiwyMA, FalconeT, 2003. Peritoneal fluid environment in endometriosis. Clinicopathological implications. Minerva Ginecol, 55(4):333-345. ![]() [11]Bhatt-WesselB, JordanTW, MillerJH, et al., 2018. Role of DGAT enzymes in triacylglycerol metabolism. Arch Biochem Biophys, 655:1-11. ![]() [12]BougarneN, WeyersB, DesmetSJ, et al., 2018. Molecular actions of PPARα in lipid metabolism and inflammation. Endocr Rev, 39(5):760-802. ![]() [13]BurkeAC, TelfordDE, EdwardsJY, et al., 2019. Naringenin supplementation to a chow diet enhances energy expenditure and fatty acid oxidation, and reduces adiposity in lean, pair-fed Ldlr-/- mice. Mol Nutr Food Res, 63(6):1800833. ![]() [14]CajasYN, Cañón-BeltránK, de GuevaraML, et al., 2020. Antioxidant nobiletin enhances oocyte maturation and subsequent embryo development and quality. Int J Mol Sci, 21(15):5340. ![]() [15]ChenHF, ZhangWG, YuanJB, et al., 2012. Simultaneous quantification of polymethoxylated flavones and coumarins in Fructus aurantii and Fructus aurantii immaturus using HPLC‒ESI-MS/MS. J Pharm Biomed Anal, 59:90-95. ![]() [16]ChenXL, WeiW, LiYZ, et al., 2019. Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. Chem Biol Interact, 308:269-278. ![]() [17]ChenY, ZhaoY, MiaoCY, et al., 2022. Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells. J Ovarian Res, 15:138. ![]() [18]ChhikaraN, KourR, JaglanS, et al., 2018. Citrus medica: nutritional, phytochemical composition and health benefits—a review. Food Funct, 9(4):1978-1992. ![]() [19]CushnieTPT, LambAJ, 2005. Antimicrobial activity of flavonoids. Int J Antimicrob Agents, 26(5):343-356. ![]() [20]da CruzLF, de FigueiredoGF, PedroLP, et al., 2020. Umbelliferone (7-hydroxycoumarin): a non-toxic antidiarrheal and antiulcerogenic coumarin. Biomed Pharmacother, 130:110843. ![]() [21]DabravolskiSA, NikiforovNG, EidAH, et al., 2021. Mitochondrial dysfunction and chronic inflammation in polycystic ovary syndrome. Int J Mol Sci, 22(8):3923. ![]() [22]DosokyNS, SetzerWN, 2018. Biological activities and safety of Citrus spp. essential oils. Int J Mol Sci, 19(7):1966. ![]() [23]DubeyP, ReddyS, BoydS, et al., 2021. Effect of nutritional supplementation on oxidative stress and hormonal and lipid profiles in PCOS-affected females. Nutrients, 13(9):2938. ![]() [24]El-SaadAMA, Abdel-WahabWM, 2020. Naringenin attenuates toxicity and oxidative stress induced by lambda-cyhalothrin in liver of male rats. Pak J Biol Sci, 23(4):510-517. ![]() [25]Fugh-BermanA, MyersA, 2004. Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research. Exp Biol Med, 229(8):698-704. ![]() [26]GaoTH, JiangMY, DengB, et al., 2021. Aurantii Fructus: a systematic review of ethnopharmacology, phytochemistry and pharmacology. Phytochem Rev, 20(5):909-944. ![]() [27]GargSS, GuptaJ, SahuD, et al., 2022. Pharmacological and therapeutic applications of esculetin. Int J Mol Sci, 23(20):12643. ![]() [28]GeMX, ShaoRG, HeHW, 2019. Advances in understanding the regulatory mechanism of cholesterol 7α-hydroxylase. Biochem Pharmacol, 164:152-164. ![]() [29]GuanGQ, ChenYX, DongYL, 2025. Unraveling the AMPK-SIRT1-FOXO pathway: the in-depth analysis and breakthrough prospects of oxidative stress-induced diseases. Antioxidants, 14(1):70. ![]() [30]GunasekaranB, ShukorMY, 2020. HMG-CoA reductase as target for drug development. In: Labrou NE (Ed.), Targeting Enzymes for Pharmaceutical Development. Humana, New York, p.245-250. ![]() [31]GünencAN, GrafB, StarkH, et al., 2022. Fatty acid synthase: structure, function, and regulation. In: Harris JR, Marles-Wright J (Eds.), Macromolecular Protein Complexes IV. Springer, Cham, p.1-33. ![]() [32]GungorANC, GencerM, KaracaT, et al., 2014. The effect of hesperetin on ischemia-reperfusion injury in rat ovary. Arch Gynecol Obstet, 290(4):763-769. ![]() [33]GuoF, GongZT, FernandoT, et al., 2022. The lipid profiles in different characteristics of women with PCOS and the interaction between dyslipidemia and metabolic disorder states: a retrospective study in Chinese population. Front Endocrinol, 13:892125. ![]() [34]HaazS, FontaineKR, CutterG, et al., 2006. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev, 7(1):79-88. ![]() [35]HarrisHR, EkeAC, ChavarroJE, et al., 2018. Fruit and vegetable consumption and risk of endometriosis. Hum Reprod, 33(4):715-727. ![]() [36]HosseinimehrSJ, TavakoliH, PourheidariG, et al., 2003. Radioprotective effects of citrus extract against γ-irradiation in mouse bone marrow cells. J Radiat Res, 44(3):237-241. ![]() [37]HuXY, WangWY, SuXH, et al., 2023. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis. PeerJ, 11:e16410. ![]() [38]JiMT, DengZ, RongXY, et al., 2023. Naringenin prevents oxidative stress and inflammation in LPS-induced liver injury through the regulation of lncRNA-mRNA in male mice. Molecules, 28(1):198. ![]() [39]JomovaK, AlomarSY, AlwaselSH, et al., 2024. Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants. Arch Toxicol, 98(5):1323-1367. ![]() [40]KarabıyıklıŞ, DeğirmenciH, KarapınarM, 2014. Inhibitory effect of sour orange (Citrus aurantium) juice on Salmonella Typhimurium and Listeria monocytogenes. LWT-Food Sci Technol, 55(2):421-425. ![]() [41]KelebekH, SelliS, 2011. Determination of volatile, phenolic, organic acid and sugar components in a Turkish cv. Dortyol (Citrus sinensis L. Osbeck) orange juice. J Sci Food Agric, 91(10):1855-1862. ![]() [42]KhanV, NajmiAK, AkhtarM, et al., 2012. A pharmacological appraisal of medicinal plants with antidiabetic potential. J Pharm Bioall Sci, 4(1):27-42. ![]() [43]KonczD, TóthB, BaharMA, et al., 2022. The safety and efficacy of Citrus aurantium (bitter orange) extracts and p-synephrine: a systematic review and meta-analysis. Nutrients, 14(19):4019. ![]() [44]KuoPC, LiaoYR, HungHY, et al., 2017. Anti-inflammatory and neuroprotective constituents from the peels of Citrus grandis. Molecules, 22(6):967. ![]() [45]LanT, WangW, HuangDL, et al., 2023. Essential oil extracted from Quzhou Aurantii Fructus prevents acute liver failure through inhibiting lipopolysaccharide-mediated inflammatory response. Nat Prod Bioprospect, 13:36. ![]() [46]LankaraniM, ValizadehN, HeshmatR, et al., 2009. Evaluation of insulin resistance and metabolic syndrome in patients with polycystic ovary syndrome. Gynecol Endocrinol, 25(8):504-507. ![]() [47]LiJD, WangTQ, LiuPP, et al., 2021. Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD. Food Funct, 12(9):3898-3918. ![]() [48]LiR, ZhangQF, YangDZ, et al., 2013. Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod, 28(9):2562-2569. ![]() [49]LiangYZ, ChenMP, HuZC, et al., 2023. Research progress on the application of Exocarpium Citri Grandis (ECG) in the field of medicine and food. Asia-Pac Tradit Med, 19(8):234-239 (in Chinese). ![]() [50]LinHY, ZhouZT, ZhongWC, et al., 2017. Naringenin inhibits alcoholic injury by improving lipid metabolism and reducing apoptosis in zebrafish larvae. Oncol Rep, 38(5):2877-2884. ![]() [51]LiuH, ZhaoH, CheJJ, et al., 2022. Naringenin protects against hypertension by regulating lipid disorder and oxidative stress in a rat model. Kidney Blood Press Res, 47(6):423-432. ![]() [52]LiuY, TangXH, YuanHL, et al., 2024. Naringin inhibits macrophage foam cell formation by regulating lipid homeostasis and metabolic phenotype. Nutrients, 16(9):1321. ![]() [53]LuXM, ZhaoCY, ShiH, et al., 2023. Nutrients and bioactives in citrus fruits: different citrus varieties, fruit parts, and growth stages. Crit Rev Food Sci Nutr, 63(14):2018-2041. ![]() [54]LuchkovaA, MataA, CadenasS, 2024. Nrf2 as a regulator of energy metabolism and mitochondrial function. FEBS Lett, 598(17):2092-2105. ![]() [55]MoazamiyanfarR, RezaeiS, AliashrafzadehH, et al., 2023. Nobiletin in cancer therapy; mechanisms and therapy perspectives. Curr Pharm Des, 29(22):1713-1728. ![]() [56]MotallebiM, BhiaM, RajaniHF, et al., 2022. Naringenin: a potential flavonoid phytochemical for cancer therapy. Life Sci, 305:120752. ![]() [57]Öner-İyidoğanY, KoçakH, GürdölF, et al., 2004. Indices of oxidative stress in eutopic and ectopic endometria of women with endometriosis. Gynecol Obstet Invest, 57(4):214-217. ![]() [58]PanGT, ZhangP, ChenAY, et al., 2023. Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1Α pathway. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(3):221-231. ![]() [59]PengJ, LiQD, LiKY, et al., 2017. Quercetin improves glucose and lipid metabolism of diabetic rats: involvement of Akt signaling and SIRT1. J Diabetes Res, 2017:3417306. ![]() [60]PyrzynskaK, 2022. Hesperidin: a review on extraction methods, stability and biological activities. Nutrients, 14(12):2387. ![]() [61]Ramírez-PelayoC, Martínez-QuiñonesJ, GilJ, et al., 2019. Coumarins from the peel of citrus grown in Colombia: composition, elicitation and antifungal activity. Heliyon, 5(6):e01937. ![]() [62]Roa BarriosM, Arata-BellabarbaG, ValeriL, et al., 2009. Relationship between the triglyceride/high-density lipoprotein-cholesterol ratio, insulin resistance index and cardiometabolic risk factors in women with polycystic ovary syndrome. Endocrinol Nutr, 56(2):59-65. ![]() [63]Sadeghi NejadZ, KazemianS, GaledariA, et al., 2023. Naringenin mitigates reserpine-induced anxiety-like behavior, neurodegeneration, and oxidative stress in male rats. Neurosci Behav Physiol, 53(4):654-660. ![]() [64]SalehiB, UpadhyayS, OrhanIE, et al., 2019. Therapeutic potential of α- and β-pinene: a miracle gift of nature. Biomolecules, 9(11):738. ![]() [65]SamecM, MazurakovaA, LucanskyV, et al., 2023. Flavonoids attenuate cancer metabolism by modulating lipid metabolism, amino acids, ketone bodies and redox state mediated by Nrf2. Eur J Pharmacol, 949:175655. ![]() [66]SchieberM, ChandelNS, 2014. ROS function in redox signaling and oxidative stress. Curr Biol, 24(10):R453-R462. ![]() [67]ScutieroG, IannoneP, BernardiG, et al., 2017. Oxidative stress and endometriosis: a systematic review of the literature. Oxid Med Cell Longev, 2017:7265238. ![]() [68]ShahidR, Iahtisham-Ul-Haq, Mahnoor, et al., 2022. Diet and lifestyle modifications for effective management of polycystic ovarian syndrome (PCOS). J Food Biochem, 46(7):e14117. ![]() [69]ShilpaVS, ShamsR, DashKK, et al., 2023. Phytochemical properties, extraction, and pharmacological benefits of naringin: a review. Molecules, 28(15):5623. ![]() [70]SiddiquiS, MateenS, AhmadR, et al., 2022. A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS). J Assist Reprod Genet, 39(11):2439-2473. ![]() [71]SiesH, 2015. Oxidative stress: a concept in redox biology and medicine. Redox Biol, 4:180-183. ![]() [72]SpitellerG, 2006. Peroxyl radicals: inductors of neurodegenerative and other inflammatory diseases. Their origin and how they transform cholesterol, phospholipids, plasmalogens, polyunsaturated fatty acids, sugars, and proteins into deleterious products. Free Radical Biol Med, 41(3):362-387. ![]() [73]SpreenTH, GaoZF, FernandesWJr, et al., 2020. Global economics and marketing of citrus products. In: Talon M, Caruso M, Gmitter FG Jr (Eds.), The Genus Citrus. Elsevier, Duxford, p.471-493. ![]() [74]StohsSJ, HartmanMJ, 2015. A review of the receptor binding and pharmacological effects of N-methyltyramine. Phytother Res, 29(1):14-16. ![]() [75]StohsSJ, PreussHG, SharaM, 2012. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci, 9(7):527-538. ![]() [76]SuDX, LiuHS, QiXY, et al., 2019. Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells. Biosci Biotechnol Biochem, 83(9):1747-1755. ![]() [77]SuZ, 2011. Functional food is an important and realistic choice for the productization of Xinhui Chenpi. Proceedings of the Third China Xinhui Chenpi Industry Development Forum, Guangdong Jiangmen. p.51-52 (in Chinese). ![]() [78]SuginoN, Karube-HaradaA, SakataA, et al., 2002. Nuclear factor-κB is required for tumor necrosis factor-α-induced manganese superoxide dismutase expression in human endometrial stromal cells. J Clin Endocrinol Metab, 87(8):3845-3850. ![]() [79]SuginoN, Karube-HaradaA, TaketaniT, et al., 2004. Withdrawal of ovarian steroids stimulates prostaglandin F2α production through nuclear factor-κB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation. J Reprod Dev, 50(2):215-225. ![]() [80]SunJH, WangZD, ChenL, et al., 2021. Hypolipidemic effects and preliminary mechanism of chrysanthemum flavonoids, its main components luteolin and luteoloside in hyperlipidemia rats. Antioxidants, 10(8):1309. ![]() [81]TaylorHS, KotlyarAM, FloresVA, 2021. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet, 397(10276):839-852. ![]() [82]TempestN, JansenM, BakerAM, et al., 2020. Histological 3D reconstruction and in vivo lineage tracing of the human endometrium. J Pathol, 251(4):440-451. ![]() [83]UçarK, GöktaşZ, 2023. Biological activities of naringenin: a narrative review based on in vitro and in vivo studies. Nutr Res, 119:43-55. ![]() [84]UyanikogluH, SabuncuT, DursunH, et al., 2017. Circulating levels of apoptotic markers and oxidative stress parameters in women with polycystic ovary syndrome: a case-controlled descriptive study. Biomarkers, 22(7):643-647. ![]() [85]VieiraAJ, BeserraFP, SouzaMC, et al., 2018. Limonene: aroma of innovation in health and disease. Chem-Biol Interact, 283:97-106. ![]() [86]WangJX, YinTL, LiuS, 2023. Dysregulation of immune response in PCOS organ system. Front Immunol, 14:1169232. ![]() [87]WangLQ, 2012. The Study of Antioxidant Health (Functional) Foods from Exocarpium Citri Grandis. MS Thesis, Guangzhou Univerity of Chinese Medicine, Guangzhou, China(in Chinese). ![]() [88]WangX, HuangJQ, YinZY, et al., 2023. Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin (Citrus reticulata Blanco) with citrine flavedo. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 24(1):94-100. ![]() [89]WangY, LiuXJ, ChenJB, et al., 2022. Citrus flavonoids and their antioxidant evaluation. Crit Rev Food Sci Nutr, 62(14):3833-3854. ![]() [90]WongHS, ChenJH, LeongPK, et al., 2015. A cistanches herba fraction/β-sitosterol causes a redox-sensitive induction of mitochondrial uncoupling and activation of adenosine monophosphate-dependent protein kinase/peroxisome proliferator-activated receptor γ coactivator-1 in C2C12 myotubes: a possible mechanism underlying the weight reduction effect. Evid Based Complement Alternat Med, 2015:142059. ![]() [91]WongHS, LeongPK, ChenJH, et al., 2016. β-Sitosterol increases mitochondrial electron transport by fluidizing mitochondrial membranes and enhances mitochondrial responsiveness to increasing energy demand by the induction of uncoupling in C2C12 myotubes: a possible mechanism underlying the weight reduction effect. J Funct Foods, 23:253-260. ![]() [92]WuGA, TerolJ, IbanezV, et al., 2018. Genomics of the origin and evolution of Citrus. Nature, 554(7692):311-316. ![]() [93]WuYX, YangXY, HanBS, et al., 2022. Naringenin regulates gut microbiota and SIRT1/PGC-1α signaling pathway in rats with letrozole-induced polycystic ovary syndrome. Biomed Pharmacother, 153:113286. ![]() [94]YamaguchiM, YoshiharaK, SudaK, et al., 2021. Three-dimensional understanding of the morphological complexity of the human uterine endometrium. iScience, 24(4):102258. ![]() [95]YangH, YangTT, HengC, et al., 2019. Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice. Phytother Res, 33(12):3140-3152. ![]() [96]YeQH, ZengXZ, CaiS, et al., 2021. Mechanisms of lipid metabolism in uterine receptivity and embryo development. Trends Endocrinol Metab, 32(12):1015-1030. ![]() [97]ZareinM, ZarbanA, ShooreiH, et al., 2023. The amelioration of ovarian dysfunction by hesperidin in malathion-treated mice through the overexpression of PCNA and FSHR proteins. Heliyon, 9(12):e22484. ![]() [98]ZengX, HuangQ, LongSL, et al., 2020. Mitochondrial dysfunction in polycystic ovary syndrome. DNA Cell Biol, 39(8):1401-1409. ![]() [99]ZhangCH, LiuXY, WangJ, 2023. Essential role of granulosa cell glucose and lipid metabolism on oocytes and the potential metabolic imbalance in polycystic ovary syndrome. Int J Mol Sci, 24(22):16247. ![]() [100]ZhangMJ, SuYQ, SugiuraK, et al., 2010. Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science, 330(6002):366-369. ![]() [101]ZhangX, DengQ, WangWJ, et al., 2023. Epsilon-poly-L-lysine increases disease resistance of citrus against postharvest green mold by activating amino acid metabolism and phenolic compounds biosynthesis. Food Qual Saf, 7:fyad010. ![]() [102]ZhangXH, ZhangYZ, GaoW, et al., 2021. Naringin improves lipid metabolism in a tissue-engineered liver model of NAFLD and the underlying mechanisms. Life Sci, 277:119487. ![]() [103]ZhangYX, ChenXJ, WangXX, et al., 2024. Hesperetin ameliorates spinal cord injury in rats through suppressing apoptosis, oxidative stress and inflammatory response. Eur J Pharmacol, 971:176541. ![]() [104]ZhaoCY, WangF, LianYH, et al., 2020. Biosynthesis of citrus flavonoids and their health effects. Crit Rev Food Sci Nutr, 60(4):566-583. ![]() [105]ZhaoP, LuY, WangZY, 2023. Naringenin attenuates cerebral ischemia/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/FOXO1 signaling pathway in vitro. Acta Cir Bras, 38:e380823. ![]() [106]ZhengSY, MaMY, ChenYX, et al., 2022. Effects of quercetin on ovarian function and regulation of the ovarian PI3K/Akt/FoxO3a signalling pathway and oxidative stress in a rat model of cyclophosphamide-induced premature ovarian failure. Basic Clin Pharmacol Toxicol, 130(2):240-253. ![]() [107]ZhuQ, HanYS, HeY, et al., 2024. Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression. Phytomedicine, 130:155560. ![]() Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou
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