JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

TRPV1: from structure to function-a multidimensional target for therapeutic advances

Author(s): Yi LIU^1, ², Fuqin DUAN^1, ², RunPeng LIN^1, ², Subinuer SHABUERJIANG^1, ², Fan YANG^4, ^5, ⁶, Aerziguli AIERKEN^1, ^2, ³
Affiliation(s): ¹Department of Physiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830017, China ²Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Urumqi 830017, China ³Scientific Research Platform of Xinjiang Medical University Key Laboratory of Neurophysiology and Clinical Translation, Urumqi 830017, China ⁴Department of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China. ⁵Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou 310058, China. ⁶Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Hangzhou 310058, China
Corresponding email(s): Fan YANG , fanyanga@zju.edu.cn Aerziguli AIERKEN , arzuuyghur @163.com
Key Words: Transient receptor potential vanilloid subtype 1 (TRPV1); Structure; Gating Mechanism; Therapeutic Target

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Yi LIU^1,², Fuqin DUAN^1,², RunPeng LIN^1,², Subinuer SHABUERJIANG^1,², Fan YANG^4,^5,⁶, Aerziguli AIERKEN^1,^2,³. TRPV1: from structure to function-a multidimensional target for therapeutic advances[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500209

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author="Yi LIU^1,², Fuqin DUAN^1,², RunPeng LIN^1,², Subinuer SHABUERJIANG^1,², Fan YANG^4,^5,⁶, Aerziguli AIERKEN^1,^2,³",
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year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500209"
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Transient receptor potential vanilloid subtype 1 (TRPV1), a polymodally activated, calcium-permeable non-selective cation channel, is broadly present in all parts of the body, with notable expression in nociceptive neurons. Both physiological and pathological functions rely heavily on this ion channel. mediating responses to a variety of stimuli and contributing to the maintenance of bodily homeostasis. Its unique ability to respond to temperature changes, chemical ligands, and voltage fluctuations positions TRPV1 as a key target in understanding and modulating normal bodily functions, in addition to diagnosing and treating diseases. This review synthesizes current knowledge on the structure, gating mechanisms, and physiological and pathological roles of TRPV1, highlighting its potential as a therapeutic target across multiple disease states. By providing a comprehensive overview of the multifaceted functions of TRPV1, this review aims to inform and inspire future research, finally contributing to the advancement of new therapeutic techniques focusing on TRPV1 to enhance human health.

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