JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes

Author(s): Yuta YANG^1, Shaoli ZHANG^1, Lei CHEN¹, Yunan HE¹, Enhui JIANG¹, Chuanying PAN¹, Yang LI¹, Chuzhao LEI¹, Jiyao WU², Xianyong LAN¹
Affiliation(s): ¹College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China ²College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Corresponding email(s): jiyao WU, wujiyao@fafu.edu.cn Xianyong LAN, lanxianyong79@126.com
Key Words: Circular RNAs (circRNA); Cattle; Adipogenesis; Beef quality; Post-transcriptional regulation

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Yuta YANG^1*, Shaoli ZHANG^1*, Lei CHEN¹, Yunan HE¹, Enhui JIANG¹, Chuanying PAN¹, Yang LI¹, Chuzhao LEI¹, Jiyao WU², Xianyong LAN¹. CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2500442

@article{title="CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes",
author="Yuta YANG^1*, Shaoli ZHANG^1*, Lei CHEN¹, Yunan HE¹, Enhui JIANG¹, Chuanying PAN¹, Yang LI¹, Chuzhao LEI¹, Jiyao WU², Xianyong LAN¹",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2500442"
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%0 Journal Article
%T CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes
%A Yuta YANG^1*
%A Shaoli ZHANG^1*
%A Lei CHEN¹
%A Yunan HE¹
%A Enhui JIANG¹
%A Chuanying PAN¹
%A Yang LI¹
%A Chuzhao LEI¹
%A Jiyao WU²
%A Xianyong LAN¹
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2500442"

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T1 - CircMED17 regulates bovine adipogenesis and fat deposition via mediating the proliferation and differentiation of bovine adipocytes
A1 - Yuta YANG^1*
A1 - Shaoli ZHANG^1*
A1 - Lei CHEN¹
A1 - Yunan HE¹
A1 - Enhui JIANG¹
A1 - Chuanying PAN¹
A1 - Yang LI¹
A1 - Chuzhao LEI¹
A1 - Jiyao WU²
A1 - Xianyong LAN¹
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2500442"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Fat deposition is a key factor influencing beef quality. Therefore, understanding the regulatory mechanisms of adipogenesis is crucial for improving meat production traits in cattle. Circular RNAs (circRNAs) have emerged as important post-transcriptional regulators in various biological processes, including adipocyte differentiation. In our study, circMED17 was identified as a stable, nuclear-localized circRNA derived from exons 2 and 3 of the MED17 gene, with its expression markedly upregulated during bovine preadipocyte differentiation, suggesting its potential role in adipogenesis. Functional analyses revealed that circMED17 inhibits preadipocyte proliferation and apoptosis while promoting differentiation and lipid accumulation. Mechanistically, circMED17 exerts dual regulatory effects by sponging miR-146b as a competing endogenous RNA (ceRNA) and by directly interacting with the transcription factor GATA2. Importantly, the in vivo overexpression of circMED17 in obese mice increased subcutaneous fat deposition, confirming its pro-adipogenic role. Collectively, the findings reveal a previously unreported dual mechanism of circMED17 in bovine adipogenesis and highlight its potential as a molecular target for improving beef quality through genetic and breeding strategies.

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