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The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches
Affiliation(s):
State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China;
moreAffiliation(s): State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; Zhejiang-Russia Joint Laboratory of Photo-Electro-Magnetic Functional Materials, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China;
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Yichuan HONG, Haojie YU, Li WANG, Xiang CHEN, Di SHEN, Yu WANG, Shuning REN, Yudi HUANG, Jian YANG. The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2300386
@article{title="The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches", author="Yichuan HONG, Haojie YU, Li WANG, Xiang CHEN, Di SHEN, Yu WANG, Shuning REN, Yudi HUANG, Jian YANG", journal="Journal of Zhejiang University Science A", year="in press", publisher="Zhejiang University Press & Springer", doi="https://doi.org/10.1631/jzus.A2300386" }
%0 Journal Article %T The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches %A Yichuan HONG %A Haojie YU %A Li WANG %A Xiang CHEN %A Di SHEN %A Yu WANG %A Shuning REN %A Yudi HUANG %A Jian YANG %J Journal of Zhejiang University SCIENCE A %P %@ 1673-565X %D in press %I Zhejiang University Press & Springer doi="https://doi.org/10.1631/jzus.A2300386"
TY - JOUR T1 - The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches A1 - Yichuan HONG A1 - Haojie YU A1 - Li WANG A1 - Xiang CHEN A1 - Di SHEN A1 - Yu WANG A1 - Shuning REN A1 - Yudi HUANG A1 - Jian YANG J0 - Journal of Zhejiang University Science A SP - EP - %@ 1673-565X Y1 - in press PB - Zhejiang University Press & Springer ER - doi="https://doi.org/10.1631/jzus.A2300386"
Abstract: To overcome the pain and risk of hypoglycemia in insulin administration, glucose-responsive microneedles have been developed by researchers, which could release insulin according to the blood glucose level. We designed a kind of particles by a RAFT method containing a phenylboronic acid group as the sensor of glucose and carrier of insulin. Polyethylene glycol (PEG)-DDMAT was synthesized as a macromolecular RAFT agent, which was then reacted with 3-acrylamidophenylboronic acid (AAPBA) to synthesize the block copolymer PEG-b-PAAPBA. Glucose-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic interactions. Microneedle patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the substrate. The insulin release behavior of the particles in glucose solutions of 0, 100, and 400 mg/dL showed significant glucose responsiveness and good biosafety. The results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 hours.
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