CLC number: R614.2
On-line Access: 2019-06-06
Received: 2018-12-31
Revision Accepted: 2019-03-26
Crosschecked: 2019-05-23
Cited: 0
Clicked: 3140
Shao-Jun Zhu, Kui-Rong Wang, Xiong-Xin Zhang, Sheng-Mei Zhu. Relationship between genetic variation in the α2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B1800647 @article{title="Relationship between genetic variation in the α2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population", %0 Journal Article TY - JOUR
中国汉族人群中肾上腺素α2A受体基因多态性与右美托咪定心血管效应的相关性研究创新点:探索右美托咪定的心血管系统反应与肾上腺素α2A受体基因多态性的关系,期望为临床个体化应用右美托咪定及其他α2受体激动剂提供重要的依据. 方法:本研究取得单位伦理委员会的批准,所有受试者告知受试内容并签署知情同意书.60例美国麻醉医师协会I-II行择期手术汉族患者根据标准入选本研究.通过静脉输注右美托咪定,记录收缩压、舒张压、心率等心血管效应数据,并用聚合酶链式反应(PCR)法检测ADRA2A基因单核苷酸多态性. 结论:中国汉族人群中肾上腺素α2A受体C-1291G基因多态性与应用右美托咪定后心率变化有相关性. 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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