CLC number: R737.31
On-line Access: 2020-04-07
Received: 2019-07-20
Revision Accepted: 2019-11-15
Crosschecked: 2020-03-03
Cited: 0
Clicked: 3580
Lin Deng, Ding-qing Feng, Bin Ling. Cyclooxygenase-2 promotes ovarian cancer cell migration and cisplatin resistance via regulating epithelial mesenchymal transition[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B1900445 @article{title="Cyclooxygenase-2 promotes ovarian cancer cell migration and cisplatin resistance via regulating epithelial mesenchymal transition", %0 Journal Article TY - JOUR
环氧合酶-2(COX-2)通过调控细胞上皮间质转化(EMT)促进卵巢癌细胞迁移及其耐药性创新点:本研究发现COX-2对卵巢癌发生发展有一定的促进作用,可以通过上皮间质转化(EMT)途径促进卵巢癌细胞的迁移和顺铂(CDDP)耐药.其抑制剂塞来昔布(CXB)能起到协同抗癌的效果. 方法:CCK-8检测CXB和CDDP对SKOV3和ES2细胞的毒性作用.划痕实验评估COX-2对卵巢癌细胞迁移的作用.蛋白质免疫印迹(western blot)和聚合酶链式反应(PCR)检测EMT相关基因和蛋白的表达水平. 结论:COX-2可以通过EMT促进卵巢癌细胞迁移和CDDP耐药;CXB可以起到抑制作用,与CDDP协同抗癌.COX-2可以作为卵巢癌治疗的一个潜在靶点. 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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