CLC number:
On-line Access: 2022-03-09
Received: 2021-09-17
Revision Accepted: 2021-12-15
Crosschecked: 0000-00-00
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Citations: Bibtex RefMan EndNote GB/T7714
Minqi CHEN, Jinyue LIANG, Yuan WANG, Yayue LIU, Chunxia ZHOU, Pengzhi HONG, Yi ZHANG, Zhong-Ji QIAN. A new benzaldehyde from the coral-derived fungus Aspergillus terreus C23-3 and its anti-inflammatory effects via suppression of MAPK signaling pathway in RAW264.7 cells[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2100807 @article{title="A new benzaldehyde from the coral-derived fungus Aspergillus terreus C23-3 and its anti-inflammatory effects via suppression of MAPK signaling pathway in RAW264.7 cells", %0 Journal Article TY - JOUR
珊瑚来源真菌土曲霉C23-3中的一种新苯甲醛通过抑制RAW264.7细胞中MAPK通路发挥抗炎作用创新点:从一株徐闻牡丹珊瑚来源的土曲霉C23-3的发酵液中所提取出来了一种新化合物1及已知天然产物2,目前这两种苯甲醛的炎症相关研究尚未有报道。此外,这两种苯甲醛在未来的炎症相关疾病中有潜在的应用前景。 方法:通过一维(1D)、二维核磁共振谱(2D NMR)、高分辨电喷雾质谱(HR-ESI-MS)和旋光性分析,得到了一种新的化合物(S)-3-(2,3-二羟基-3-甲基丁基)-4-羟基苯甲醛。运用免疫印迹法、酶联免疫吸附试验(ELISA)、免疫荧光法和分子对接等方法,并通过研究一氧化氮(NO)、活性氧(ROS)、诱导型一氧化氮合酶(iNOS)、环氧合酶-2(COX-2)、白细胞介素-6(IL-6)、丝裂原活化蛋白激酶(MAPK)和核因子-κB(NF-κB)信号通路的表达来探讨其抗炎作用。 结论:这两种苯甲醛具有显著的抗炎能力,是iNOS、COX-2、c-Jun氨基末端激酶(JNK)、细胞外调节蛋白激酶(ERK)和p38的潜在抑制剂。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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