CLC number:
On-line Access: 2022-06-08
Received: 2021-12-28
Revision Accepted: 2022-02-14
Crosschecked: 2022-06-08
Cited: 0
Clicked: 1321
Citations: Bibtex RefMan EndNote GB/T7714
Jingjing LU, Shoupeng FU, Jie DAI, Jianwen HU, Shize LI, Hong JI, Zhiquan WANG, Jiahong YU, Jiming BAO, Bin XU, Jingru GUO, Huanmin YANG. Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2101091 @article{title="Integrated metabolism and epigenetic modifications in the macrophages of mice in responses to cold stress", %0 Journal Article TY - JOUR
冷应激下小鼠巨噬细胞的代谢和表观遗传修饰反应1黑龙江八一农垦大学动物科技学院,中国大庆市,163319 2吉林大学动物医学学院,中国长春市,130062 3上海拜谱生物科技有限公司,中国上海市,201100 4阿尔伯塔大学农业、生命与环境科学学院,加拿大埃德蒙顿,Alberta T5J 4P6 摘要:低温对健康的负面影响容易诱发多种疾病,因此我们试图通过研究冷暴露后巨噬细胞微调的机制来了解冷应激诱发疾病的原因。在本研究中,我们发现冷应激会引发巨噬细胞活化增加,并伴随有氧糖酵解的代谢重编程,而且冷暴露后的线粒体缺陷可能有助于这一过程。全基因组RNA测序的结果进一步确定了冷暴露后小鼠巨噬细胞中的线粒体缺陷。此外,新陈代谢的变化通过影响组蛋白修饰来驱动巨噬细胞的分化。最后,我们发现组蛋白乙酰化和乳酸化是冷暴露后巨噬细胞分化的调节剂。总而言之,代谢相关的表观遗传修饰对于冷应激小鼠巨噬细胞的分化至关重要,而代谢调控可能有助于减轻冷应激的危害。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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