CLC number:
On-line Access: 2023-02-05
Received: 2022-03-28
Revision Accepted: 2022-10-20
Crosschecked: 2023-02-09
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Citations: Bibtex RefMan EndNote GB/T7714
Yunzi ZHAO, Hui LI, Qinglong GUO, Hui HUI. Multiple characteristic alterations and available therapeutic strategies of cellular senescence[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2200178 @article{title="Multiple characteristic alterations and available therapeutic strategies of cellular senescence", %0 Journal Article TY - JOUR
细胞衰老的多种特征变化及可行治疗策略江苏省肿瘤发生与干预重点实验室, 中国药科大学, 江苏南京, 210009 概要:衰老的细胞通常处于一种稳定的增殖抑制状态,因此细胞衰老最初被认为是生物体延缓癌症进展的重要机制。细胞在衰老时通常伴随着一系列特征和功能的改变,如代谢迁移、干性诱导以及微环境重塑等。然而,近年来研究表明,细胞衰老参与了机体一系列生理学和病理学的变化,进一步增加了其复杂性。生物体如何通过适应性变化来规避衰老带来的不利影响是当前研究的热点之一。目前,针对细胞衰老的疗法,包括衰老细胞裂解、衰老形态学纠正、衰老免疫疗法以及功能恢复等,已经在特定的情境下取得初步成果。在这篇综述中,我们详细描述了细胞衰老相关的特征变化,并总结了当前衰老治疗可行的策略。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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