CLC number:
On-line Access: 2022-11-15
Received: 2022-04-21
Revision Accepted: 2022-07-22
Crosschecked: 2022-11-16
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Yunlong CHENG, Shu LIAN, Shuhui LI, Yusheng LU, Jie WANG, Xiaoxiao DENG, Shengyi ZHAI, Lee JIA. Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2200232 @article{title="Combination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy", %0 Journal Article TY - JOUR
L-Se-甲基硒代半胱氨酸、D-α-生育酚琥珀酸酯、β-胡萝卜素和L-赖氨酸联合作为辅助治疗手段可预防肿瘤转移1闽江学院材料与化学工程学院智能药物闽台港澳科技合作基地,福建福州,350108 2福州大学化学学院,肿瘤转移预警与预防研究中心,福建省肿瘤转移化学预防重点实验室,福建福州,350002 3闽江学院福州海洋研究院,福建福州,350108 目的:通过手术切除和辅助疗法治疗原发性肿瘤已被广泛研究,但对于肿瘤转移的有效治疗策略和药物仍然缺乏。本研究中,我们提出了一种基于组合化合物的功能性产品用作肿瘤辅助治疗,各化合物机制明确,可抑制癌症转移、改善抗癌治疗、增强免疫力和抗氧化。该组合由四种廉价化合物组成: 方法:通过体外实验研究MVBL对细胞活力、细胞周期、细胞凋亡、细胞迁移、细胞侵袭、活性氧(ROS)和紫杉醇(PTX)联合治疗的影响。在动物水平测定了MVBL在体内的抗氧化和免疫增强能力。通过小鼠肿瘤模型测定MVBL在体内对肿瘤转移的抑制。 结果:MVBL对肿瘤细胞的毒性高于对正常细胞的毒性。它没有显著性地影响癌细胞的细胞周期,但增加了细胞凋亡。划痕、粘附和侵袭实验结果表明,MVBL显著抑制肿瘤细胞迁移、粘附和侵袭。MVBL使乳腺癌MDA-MB-231细胞对PTX更敏感,表明它可以作为佐剂来增强化疗药物的治疗效果。小鼠实验数据表明,MVBL可以抑制肿瘤转移,延长其生存时间,增强其抗氧化能力和免疫功能。 结论:本研究揭示了MVBL在提高免疫、抗氧化、防止肿瘤生长和抑制体内外转移方面的作用。MVBL可用作癌症治疗的辅助药物,提高癌症患者的生存率和生活质量。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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