CLC number:
On-line Access: 2023-03-10
Received: 2022-07-19
Revision Accepted: 2022-12-07
Crosschecked: 2023-03-13
Cited: 0
Clicked: 864
Citations: Bibtex RefMan EndNote GB/T7714
Xuwentai LIU, Yue WU, Yanyi LI, Kaiming LI, Siyuan HOU, Ming DING, Jingmin TAN, Zijing ZHU, Yingqi TANG, Yuming LIU, Qianhui SUN, Cong WANG, Can ZHANG. Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2200383 @article{title="Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)", %0 Journal Article TY - JOUR
维生素D受体(VDR)通过调节M2巨噬细胞外泌体SMAP-5介导肝星状细胞的静息中国药科大学高端药物制剂与材料研究中心, 江苏省代谢性疾病药物重点实验室, "天然药物活性组分与药效"国家重点实验室, 中国南京市, 210009 概要: 肝纤维化有效治疗方案的制定需要深入了解其发病机制。肝纤维化的特征是活化的肝星状细胞(aHSC)过度产生细胞外基质。尽管已证实M2巨噬细胞能促进HSC活化,但所涉及的分子机制仍不明确。在此,我们提出参与巨噬细胞极化的维生素D受体(VDR)可能通过改变巨噬细胞外泌体的功能来调节巨噬细胞和HSC之间的通信。本研究证实,激动VDR可以抑制M2巨噬细胞对HSC活化的促进作用。源自M2巨噬细胞的外泌体可以促进HSC活化,同时激动VDR改变了M2外泌体中的蛋白质组分并逆转其激活HSC的作用。平滑肌细胞相关蛋白5(SMAP-5)被发现是M2巨噬细胞外泌体促进HSC活化的关键效应蛋白,其作用机制是通过调节HSC的自噬通量。基于这些结果表明,VDR激动剂和巨噬细胞外泌体分泌抑制剂的联合治疗可获得更加优异的抗肝纤维化效果。本研究旨在阐明VDR和巨噬细胞在HSC激活中的关联,其结果有助于对肝纤维化的发病机制理解,并为肝纤维化的治疗提供潜在的靶点。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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