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Yirui LU


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Micropeptides: origins, identification, and potential role in metabolism-related diseases

Author(s):  Yirui LU, Yutong RAN, Hong LI, Jiao WEN, Xiaodong CUI, Xiaoyun ZHANG, Xiumei GUAN, Min CHENG

Affiliation(s):  School of Basic Medicine Sciences, Weifang Medical University, Weifang 261053, China

Corresponding email(s):  mincheng@wfmc.edu.cn

Key Words:  Energy metabolism; Micropeptides; Mitochondria; Noncoding RNA (ncRNA); Small open reading frame (sORF)

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Yirui LU, Yutong RAN, Hong LI, Jiao WEN, Xiaodong CUI, Xiaoyun ZHANG, Xiumei GUAN, Min CHENG. Micropeptides: origins, identification, and potential role in metabolism-related diseases[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300128

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journal="Journal of Zhejiang University Science B",
year="in press",
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%T Micropeptides: origins, identification, and potential role in metabolism-related diseases
%A Yirui LU
%A Yutong RAN
%A Hong LI
%A Jiao WEN
%A Xiaodong CUI
%A Xiaoyun ZHANG
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%J Journal of Zhejiang University SCIENCE B
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A1 - Yirui LU
A1 - Yutong RAN
A1 - Hong LI
A1 - Jiao WEN
A1 - Xiaodong CUI
A1 - Xiaoyun ZHANG
A1 - Xiumei GUAN
A1 - Min CHENG
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With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides (miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function. MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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