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On-line Access: 2023-12-08

Received: 2023-02-24

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 ORCID:

Yirui LU

https://orcid.org/0000-0002-2814-5805

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Journal of Zhejiang University SCIENCE B

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Micropeptides: origins, identification, and potential role in metabolism-related diseases


Author(s):  Yirui LU, Yutong RAN, Hong LI, Jiao WEN, Xiaodong CUI, Xiaoyun ZHANG, Xiumei GUAN, Min CHENG

Affiliation(s):  School of Basic Medicine Sciences, Weifang Medical University, Weifang 261053, China

Corresponding email(s):  mincheng@wfmc.edu.cn

Key Words:  Energy metabolism; Micropeptides; Mitochondria; Noncoding RNA (ncRNA); Small open reading frame (sORF)


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Yirui LU, Yutong RAN, Hong LI, Jiao WEN, Xiaodong CUI, Xiaoyun ZHANG, Xiumei GUAN, Min CHENG. Micropeptides: origins, identification, and potential role in metabolism-related diseases[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300128

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author="Yirui LU, Yutong RAN, Hong LI, Jiao WEN, Xiaodong CUI, Xiaoyun ZHANG, Xiumei GUAN, Min CHENG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300128"
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%T Micropeptides: origins, identification, and potential role in metabolism-related diseases
%A Yirui LU
%A Yutong RAN
%A Hong LI
%A Jiao WEN
%A Xiaodong CUI
%A Xiaoyun ZHANG
%A Xiumei GUAN
%A Min CHENG
%J Journal of Zhejiang University SCIENCE B
%P 1106-1122
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300128"

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T1 - Micropeptides: origins, identification, and potential role in metabolism-related diseases
A1 - Yirui LU
A1 - Yutong RAN
A1 - Hong LI
A1 - Jiao WEN
A1 - Xiaodong CUI
A1 - Xiaoyun ZHANG
A1 - Xiumei GUAN
A1 - Min CHENG
J0 - Journal of Zhejiang University Science B
SP - 1106
EP - 1122
%@ 1673-1581
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PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300128"


Abstract: 
With the development of modern sequencing techniques and bioinformatics, genomes that were once thought to be noncoding have been found to encode abundant functional micropeptides (miPs), a kind of small polypeptides. Although miPs are difficult to analyze and identify, a number of studies have begun to focus on them. More and more miPs have been revealed as essential for energy metabolism homeostasis, immune regulation, and tumor growth and development. Many reports have shown that miPs are especially essential for regulating glucose and lipid metabolism and regulating mitochondrial function. MiPs are also involved in the progression of related diseases. This paper reviews the sources and identification of miPs, as well as the functional significance of miPs for metabolism-related diseases, with the aim of revealing their potential clinical applications.

微肽:起源、鉴定及其在代谢相关疾病中的作用

卢怡睿,冉雨桐,李宏,温娇,崔晓栋,张晓芸,官秀梅,成敏
潍坊医学院基础医学院,中国潍坊市,261053
摘要:随着现代测序和生物信息学技术的进展,曾被认为不具有编码功能的基因组已被证实能编码功能性小多肽--微肽(miPs)。尽管miPs的鉴定和分析仍较困难,但miPs已进入了许多研究者的视野。越来越多的miPs被发现在能量代谢、免疫调节和肿瘤生长发育中发挥重要作用。有研究表明,在代谢相关疾病中,miPs可调节糖脂代谢和线粒体功能。本文对miPs来源、鉴定及在代谢相关疾病中的作用和意义进行综述,以期揭示其潜在的临床价值。

关键词组:能量代谢;微肽;线粒体;非编码RNA(ncRNA);小开放阅读框(sORF)

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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