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On-line Access: 2023-08-28

Received: 2023-02-28

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Journal of Zhejiang University SCIENCE B

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Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells


Author(s):  Fulong NAN, Wenlong NAN, Xin YAN, Hui WANG, Shasha JIANG, Shuyun ZHANG, Zhongjie YU, Xianjuan ZHANG, Fengjun LIU, Jun LI, Xiaoqiong ZHOU, Delei NIU, Yiquan LI, Wei WANG, Ning SHI, Ningyi JIN, Changzhan XIE, Xiaoni CUI, He ZHANG, Bin WANG, Huijun LU

Affiliation(s):  Department of Special Medicine, Department of Pathogenic Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, 266071, China; more

Corresponding email(s):  huijun_lu@126.com, Wangbin532@126.com

Key Words:  Newcastle disease virus; Dendritic cells; IL-12; T cells; Immunosuppression


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Fulong NAN, Wenlong NAN, Xin YAN, Hui WANG, Shasha JIANG, Shuyun ZHANG, Zhongjie YU, Xianjuan ZHANG, Fengjun LIU, Jun LI, Xiaoqiong ZHOU, Delei NIU, Yiquan LI, Wei WANG, Ning SHI, Ningyi JIN, Changzhan XIE, Xiaoni CUI, He ZHANG, Bin WANG, Huijun LU. Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300134

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author="Fulong NAN, Wenlong NAN, Xin YAN, Hui WANG, Shasha JIANG, Shuyun ZHANG, Zhongjie YU, Xianjuan ZHANG, Fengjun LIU, Jun LI, Xiaoqiong ZHOU, Delei NIU, Yiquan LI, Wei WANG, Ning SHI, Ningyi JIN, Changzhan XIE, Xiaoni CUI, He ZHANG, Bin WANG, Huijun LU",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300134"
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%T Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells
%A Fulong NAN
%A Wenlong NAN
%A Xin YAN
%A Hui WANG
%A Shasha JIANG
%A Shuyun ZHANG
%A Zhongjie YU
%A Xianjuan ZHANG
%A Fengjun LIU
%A Jun LI
%A Xiaoqiong ZHOU
%A Delei NIU
%A Yiquan LI
%A Wei WANG
%A Ning SHI
%A Ningyi JIN
%A Changzhan XIE
%A Xiaoni CUI
%A He ZHANG
%A Bin WANG
%A Huijun LU
%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2300134"

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T1 - Newcastle disease virus suppresses antigen presentation via inhibiting IL-12 expression in dendritic cells
A1 - Fulong NAN
A1 - Wenlong NAN
A1 - Xin YAN
A1 - Hui WANG
A1 - Shasha JIANG
A1 - Shuyun ZHANG
A1 - Zhongjie YU
A1 - Xianjuan ZHANG
A1 - Fengjun LIU
A1 - Jun LI
A1 - Xiaoqiong ZHOU
A1 - Delei NIU
A1 - Yiquan LI
A1 - Wei WANG
A1 - Ning SHI
A1 - Ningyi JIN
A1 - Changzhan XIE
A1 - Xiaoni CUI
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A1 - Bin WANG
A1 - Huijun LU
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PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300134"


Abstract: 
As a potential vectored vaccine, Newcastle disease virus has been subject to various studies for vaccine development, while relatively little research has outlined the immunomodulatory effect of the virus in antigen presentation. To elucidate the key inhibitory factor in regulating the interaction of infected dendritic cells and T cells, dendritic cells were pretreated with the Newcastle disease virus vaccine strain LaSota as an inhibitor and stimulated with LPS for further detection by ELISA, flow cytometry, immunoblotting, and qRT-PCR. The results revealed that Newcastle disease virus infection resulted in the inhibition of IL-12p40 in dendritic cells through a p38 MAPK-dependent manner, thus inhibiting the synthesis of IL-12p70, leading to the reduction in of T cell proliferation and the secretion of IFN-γ, TNF-α and IL-6 induced by dendritic cells. Consequently, downregulated cytokines accelerated the infection and viral transmission from dendritic cells to T cells. Furthermore, several other strains of Newcastle disease virus also exhibited inhibitory activities. The current study reveals that Newcastle disease virus can modulate the intensity of the innate-adaptive immune cell crosstalk critically toward viral invasion improvement, highlighting a novel mechanism of virus-induced immunosuppression and providing new perspectives on the improvement of Newcastle disease virus vectored vaccine.

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