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On-line Access: 2023-11-24

Received: 2023-04-19

Revision Accepted: 2023-10-23

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Journal of Zhejiang University SCIENCE B

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Hepatitis B virus infection, infertility and assisted reproduction


Author(s):  Lingjian ZHANG, Fangfang ZHANG, Zhiyuan MA, Jie JIN

Affiliation(s):  Department of Infectious Diseases, Affiliated Hangzhou First People’s Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China; more

Corresponding email(s):  jinjie0429@163.com, zhiyuan_ma@zju.edu.cn

Key Words:  Assisted reproductive technology; Hepatitis B virus; Immunosuppressive agents; Pregnancy


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Lingjian ZHANG, Fangfang ZHANG, Zhiyuan MA, Jie JIN. Hepatitis B virus infection, infertility and assisted reproduction[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300261

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author="Lingjian ZHANG, Fangfang ZHANG, Zhiyuan MA, Jie JIN",
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publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300261"
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doi="https://doi.org/10.1631/jzus.B2300261"

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T1 - Hepatitis B virus infection, infertility and assisted reproduction
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Abstract: 
Background: Hepatitis B virus (HBV) is one of the most widespread viruses worldwide and a major cause of hepatitis, cirrhosis and hepatocellular carcinoma. Previous studies have revealed the impacts of HBV infection on fertility. An increasing number of infertile couples with chronic hepatitis B (CHB) virus infection choose assisted reproductive technology (ART) to meet their fertility needs. Despite the high prevalence of HBV, the effects of HBV infection on assisted reproduction treatment remain limited and contradictory. Aim: The aim of this study was to provide a comprehensive overview of the effect of HBV infection on fertility and discuss its effects on pregnancy outcomes, vertical transmission, pregnancy complications, and viral activity during ART treatment. Methods: We conducted a literature search in PubMed for studies on HBV infection and ART published from 1996 to 2022. Results: HBV infection negatively affected fertility in both males and females. Existing research shows that HBV infection may increase the risk of pregnancy complications in couples undergoing assisted reproduction treatment. The impact of HBV infection on the pregnancy outcomes of ART is still controversial. Current evidence does not support that ART increases the risk of vertical transmission of HBV, while relevant studies are limited. With the development of ART, the risk of HBV reactivation (HBVr) is increasing, especially due to the wide application of immunosuppressive therapy. Conclusion: Regular HBV infection screening and HBVr risk stratification and management are essential to prevent HBVr during ART. The determination of optimal strategy and timing of prophylactic anti-HBV therapy during ART still need further investigation.

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