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On-line Access: 2023-12-08

Received: 2023-04-30

Revision Accepted: 2023-06-02

Crosschecked: 2023-12-12

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Journal of Zhejiang University SCIENCE B

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Proapoptotic protein Bim regulates the suppressive function of Treg cells

Author(s):  Di WU

Affiliation(s):  Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):  diwu@zju.edu.cn

Key Words:  Regulatory T cells; Bim; Tumor immune therapy; Senescence of immune system

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Di WU. Proapoptotic protein Bim regulates the suppressive function of Treg cells[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300288

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Regulatory T (Treg) cells are a special immunosuppressive subset of cluster of differentiation 4-positive (CD4+‍)‍-T lymphocytes and play a pivotal role in the establishment of immune homeostasis in vivo (Zhang et al., 2021). The transcription factor forkhead box protein P3 (Foxp3) is the master marker of Treg cells, which is highly expressed in Treg cells and is also essential for their suppressive function (Hori et al., 2003). In addition to Foxp3, other regulators of Treg cells have been discovered (Wu et al., 2017, 2022; Wu and Sun, 2023a, 2023b); however, a deeper understanding of the regulation of these cells is required.




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