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On-line Access: 2023-10-17

Received: 2023-07-09

Revision Accepted: 2023-08-29

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Journal of Zhejiang University SCIENCE B

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New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside


Author(s):  Menglin LIU, Genhao FAN, Lingkai MENG, Kuo YANG, Huayi LIU

Affiliation(s):  Tianjin University of Traditional Chinese Medicine, Tianjin 301600, China; more

Corresponding email(s):  15900369830@163.com

Key Words:  Depression; Gastrointestinal disorders; Gut-brain axis; Pathomechanism; Treatment


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Menglin LIU, Genhao FAN, Lingkai MENG, Kuo YANG, Huayi LIU. New perspectives on microbiome-dependent gut-brain pathways for the treatment of depression with gastrointestinal symptoms: from bench to bedside[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300343

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Abstract: 
Patients with depression are more likely to have chronic gastrointestinal (GI) symptoms than the general population, but such symptoms are considered only somatic symptoms of depression and lack special attention. There is a chronic lack of appropriate diagnosis and effective treatment for patients with depression with GI symptoms, and studying the association between depression and GI disorders (GIDs) is extremely important for clinical management. There is growing evidence that depression is closely related to the microbiota present in the GI tract, and the microbiota-gut-brain axis (MGBA) is creating a new perspective on the association between depression and GIDs. Identifying and treating GIDs would provide a key opportunity to prevent episodes of depression and may also improve the outcome of refractory depression. Current studies on depression and the microbially related gut-brain axis (GBA) lack a focus on GI function. In this review, we combine preclinical and clinical evidence to summarize the role of the microbial-regulated GBA in emotions and GI function, and summarize potential therapeutic strategies to provide a reference for the study of the pathomechanism and treatment of depression in combination with GI symptoms.

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