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On-line Access: 2023-09-11

Received: 2023-06-11

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Journal of Zhejiang University SCIENCE B

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Advances in the study of mitophagy in osteoarthritis

Author(s):  Hong CAO, Xuchang ZHOU, Bowen XU, Han HU, Jianming GUO, Miao WANG, Nan LI, Jun ZOU

Affiliation(s):  Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai 200438, China; more

Corresponding email(s):  junzou@sus.edu.cn, linan@immunol.org

Key Words:  Mitophagy; Osteoarthritis; Chondrocyte; Mitochondria; Apoptosis

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Hong CAO, Xuchang ZHOU, Bowen XU, Han HU, Jianming GUO, Miao WANG, Nan LI, Jun ZOU. Advances in the study of mitophagy in osteoarthritis[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300402

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Osteoarthritis (OA), characterized by cartilage degeneration, synovial inflammation and subchondral bone remodeling, is among the most common musculoskeletal disorders globally in people over 60 years of age. The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process. Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism. Therefore, maintaining mitochondrial homeostasis is an important strategy to mitigate OA. Mitophagy is a vital process for autophagosomes to target, engulf and remove damaged and dysfunctional mitochondria, thereby maintaining mitochondrial homeostasis. Cumulative studies have revealed a strong association between mitophagy and OA, suggesting that the regulation of mitophagy may be a novel therapeutic direction for OA. By reviewing the literature on mitophagy and OA published in recent years, this paper elaborates the potential mechanism of mitophagy regulating OA, thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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