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On-line Access: 2023-11-17

Received: 2023-06-12

Revision Accepted: 2023-11-08

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Journal of Zhejiang University SCIENCE B

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Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine


Author(s):  Mingtao LIU, Li LIU, Jiaxi CHEN, Zhifeng HUANG, Huiqing ZHU, Shengxuan LIN, Weitian QI, Zhangkai J. CHENG, Ning LI, Baoqing SUN

Affiliation(s):  Department of Clinical Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510140, China; more

Corresponding email(s):  sunbaoqing@vip.163.com, lining1971@139.com

Key Words:  Thirteen serum biochemical indexes; Five whole blood coagulation indices; Point-of-care testing; Pulmonary and critical care medicine; Diagnostic protocol


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Mingtao LIU, Li LIU, Jiaxi CHEN, Zhifeng HUANG, Huiqing ZHU, Shengxuan LIN, Weitian QI, Zhangkai J. CHENG, Ning LI, Baoqing SUN. Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300433

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author="Mingtao LIU, Li LIU, Jiaxi CHEN, Zhifeng HUANG, Huiqing ZHU, Shengxuan LIN, Weitian QI, Zhangkai J. CHENG, Ning LI, Baoqing SUN",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300433"
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%0 Journal Article
%T Thirteen serum biochemical indexes and five whole blood coagulation indices in a point-of-care testing analyzer: ideal protocol for evaluating pulmonary and critical care medicine
%A Mingtao LIU
%A Li LIU
%A Jiaxi CHEN
%A Zhifeng HUANG
%A Huiqing ZHU
%A Shengxuan LIN
%A Weitian QI
%A Zhangkai J. CHENG
%A Ning LI
%A Baoqing SUN
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300433"

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A1 - Mingtao LIU
A1 - Li LIU
A1 - Jiaxi CHEN
A1 - Zhifeng HUANG
A1 - Huiqing ZHU
A1 - Shengxuan LIN
A1 - Weitian QI
A1 - Zhangkai J. CHENG
A1 - Ning LI
A1 - Baoqing SUN
J0 - Journal of Zhejiang University Science B
SP -
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%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300433"


Abstract: 
Background: The accurate and timely detection of biochemical coagulation indicators is pivotal in pulmonary and critical care medicine. Despite their reliability, traditional laboratories often lag in terms of rapid diagnosis. Point-of-care testing (POCT) has emerged as a promising alternative, which is awaiting rigorous validation. Methods: We assessed 226 samples from patients at the First Affiliated Hospital of Guangzhou Medical University using a Beckman Coulter AU5821 and a PUSHKANG POCT biochemistry analyzer. Furthermore, 350 samples were evaluated with a Stago coagulation analyzer STAR MAX and a PUSHKANG POCT coagulation analyzer. Metrics included thirteen biochemical indexes, such as albumin, and five coagulation indices like prothrombin time. Comparisons were drawn against the PUSHKANG POCT analyzer. Results: Bland–Altman plots (MS100: 0.8206-0.9995; MC100: 0.8318-0.9911) evinced significant consistency between methodologies. Spearman correlation pinpointed a potent linear association between conventional devices and the PUSHKANG POCT analyzer, further underscored by a robust correlation coefficient (MS100: 0.713-0.949; MC100: 0.593-0.950). Conclusions: The PUSHKANG POCT was validated as a dependable tool for serum and whole blood biochemical and coagulation diagnostics. This emphasizes its prospective clinical efficacy, offering clinicians a swift diagnostic tool and heralding a new era of enhanced patient care outcomes.

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