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On-line Access: 2023-10-23

Received: 2023-06-26

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Journal of Zhejiang University SCIENCE B

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The role of THEM4 in the Akt pathway: a double-edged sword


Author(s):  Wen XIE, Weidong LIU, Lei WANG, Bin ZHU, Cong ZHAO, Ziling LIAO, Yihan LI, Xingjun JIANG, Jie LIU, Caiping REN

Affiliation(s):  NHC Key Laboratory of Carcinogenesis, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; more

Corresponding email(s):  rencaiping@csu.edu.cn, braindream@163.com, wemcy111@163.com

Key Words:  Akt; THEM4; Disease


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Wen XIE, Weidong LIU, Lei WANG, Bin ZHU, Cong ZHAO, Ziling LIAO, Yihan LI, Xingjun JIANG, Jie LIU, Caiping REN. The role of THEM4 in the Akt pathway: a double-edged sword[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300457

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year="in press",
publisher="Zhejiang University Press & Springer",
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Abstract: 
The Akt pathway is involved in stem cell self-renewal and the maintenance of pluripotency, as well as in regulating the growth, proliferation, and metabolism of cancer cells through the activation of multiple downstream target genes, affecting the development and treatment of a range of diseases. THEM4 is a member of the thioesterase superfamily and one of the Akt kinase binding proteins. In studies on the mechanism of cancers and other diseases, it has been found that THEM4 regulates the phosphorylation of Akt by binding with Akt. Initially, it was considered an endogenous inhibitor of Akt, but later, some studies showed that THEM4 could positively regulate the activity of Akt. In this review, we describe the important role played by THEM4 in the Akt pathway. We focused on THEM4 as an Akt-binding protein, and the regulatory relationship with Akt phosphorylation in various diseases, especially cancer. This work allows for a better understanding of the role of THEM4 combined with Akt in the treatment of diseases.

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