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On-line Access: 2024-02-01

Received: 2023-08-17

Revision Accepted: 2023-11-08

Crosschecked: 2024-02-02

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Gao CHEN

https://orcid.org/0000-0003-1085-0028

Xiaotong ZHANG

https://orcid.org/0000-0002-9197-1421

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Journal of Zhejiang University SCIENCE B

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A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS


Author(s):  Yi ZHANG, Zhiyan QUAN, Feiyang LOU, Yujiao FANG, Garth J. THOMPSON, Gao CHEN, Xiaotong ZHANG

Affiliation(s):  Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University,Hangzhou310009,China; more

Corresponding email(s):  d-chengao@zju.edu.cn, zhangxiaotong@zju.edu.cn

Key Words:  Energy metabolism; Magnetic resonance imaging (MRI); Magnetic resonance spectroscopy (MRS); Multi-nuclear; Radiofrequency coil; Three-dimensional (3D) printing


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Yi ZHANG, Zhiyan QUAN, Feiyang LOU, Yujiao FANG, Garth J. THOMPSON, Gao CHEN, Xiaotong ZHANG. A proton birdcage coil integrated with interchangeable single loops for multi-nuclear MRI/MRS[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300587

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Abstract: 
Energy metabolism is fundamental for life. It encompasses the utilization of carbohydrates, lipids, and proteins for internal processes, while aberrant energy metabolism is implicated in many diseases. In the present study, using three-dimensional (3D) printing from polycarbonate via fused deposition modeling, we propose a multi-nuclear radiofrequency (RF) coil design with integrated1H birdcage and interchangeable X-nuclei (2H,13C,23Na, and31P) single-loop coils for magnetic resonance imaging (MRI)/magnetic resonance spectroscopy (MRS). The single-loop coil for each nucleus attaches to an arc bracket that slides unrestrictedly along the birdcage coil inner surface, enabling convenient switching among various nuclei and animal handling. Compared to a commercial1H birdcage coil, the proposed1H birdcage coil exhibited superior signal-excitation homogeneity and imaging signal-to-noise ratio (SNR). For X-nuclei study, prominent peaks in spectroscopy for phantom solutions showed excellent SNR, and the static and dynamic peaks of in vivo spectroscopy validated the efficacy of the coil design in structural imaging and energy metabolism detection simultaneously.

一种用于多核磁共振成像及波谱的鸟笼线圈与可更换单环线圈的一体化设计

张怡1,2,3,全枝艳3,4,楼飞洋3,4,5,方玉娇6,Garth J. THOMPSON6,陈高1,2,张孝通1,2,3,4,5,7
1浙江大学医学院附属第二医院神经外科,中国杭州市,310009
2浙江省神经外科疾病精准诊治及临床转化重点实验室,中国杭州市,310009
3浙江大学教育部脑与脑机融合前沿科学中心,中国杭州市,310058
4浙江大学系统神经与认知科学研究所,中国杭州市,310027
5浙江大学医学院,中国杭州市,310020
6上海科技大学iHuman研究所,中国上海市,201210
7浙江大学电气工程学院,中国杭州市,310027
摘要:能量代谢对生命活动至关重要,主要包括对碳水化合物、脂肪和蛋白质的利用过程,异常的能量代谢与诸多疾病密切相关。本研究提出了一种用于多核磁共振成像(MRI)与波谱(MRS)的射频线圈设计:通过3D打印线圈外壳和支架,将一个鸟笼1H线圈和可更换的单环X核(2H、13C、23Na和31P)线圈一体化集成,其中单环线圈通过一个弧形支架安装于鸟笼线圈内壁,使其可沿内壁轴向无阻碍地移动,方便实现成像实验中多核线圈的更换以及线圈相对于不同成像体的摆放。与商用鸟笼1H核线圈相比,本设计具有更好的1H信号激发均匀性和成像信噪比;小鼠的活体实验验证了线圈设计在成像与波谱研究方面的可行性与有效性,可同时满足结构成像和能量代谢检测的要求。综上所述,该多核线圈通过新型机械与电路设计可以简化多核磁共振成像能量代谢检测的实施过程。

关键词组:能量代谢;核磁共振成像;磁共振波谱;多核;射频线圈;3D打印

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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