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On-line Access: 2023-05-15

Received: 2023-03-16

Revision Accepted: 2023-05-08

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B

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Cellulose nanofibril matrix drives the dynamic formation of spheroids


Author(s):  Yi LU, Guo LI, Yeqiu LI, Yuan YAO

Affiliation(s):  College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang, 310027, China; more

Corresponding email(s):  yyao1@zju.edu.cn

Key Words:  Cellulose; Nanofibril; Matrix; Self-Assembly; Spheroid


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Yi LU, Guo LI, Yeqiu LI, Yuan YAO. Cellulose nanofibril matrix drives the dynamic formation of spheroids[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B23Z0003

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Abstract: 
Multicellular spheroids, which mimic the natural organ counterparts, allow the prospect of drug screening and regenerative medicine. However, their application is hampered by low processing efficiency or limited scale. This study introduces an efficient method to drive rapid multicellular spheroid formation by a cellulose nanofibril matrix. This matrix enables the facilitated growth of spheroids (within 48 hours) through multiple cell assembly into size-controllable aggregates with well-organized physiological microstructure. The efficiency, dimension, and conformation of the as-formed spheroids depend on the concentration of extracellular nanofibrils, the number of assembled cells, and the heterogeneity of cell types. The above strategy allows the robust formation mechanism of compacted tumoroids and hepatocyte spheroids.

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