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On-line Access: 2023-06-26
Received: 2023-03-16
Revision Accepted: 2023-05-08
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Yi LU, Guo LI, Yeqiu LI, Yuan YAO. Cellulose nanofibril matrix drives the dynamic formation of spheroids[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B23d0003 @article{title="Cellulose nanofibril matrix drives the dynamic formation of spheroids", %0 Journal Article TY - JOUR
纳米纤维素基质驱动类器官微球形成1浙江大学化学工程与生物工程学院, 中国杭州市, 310027 2浙江大学杭州国际科创中心, 中国杭州市, 311215 3上海科技大学物质科学与技术学院, 中国上海市, 201210 摘要:模仿天然组织器官的类器官多细胞微球在药物筛选和再生医学等领域具有广泛前景。然而,多细胞微球技术面临一些挑战,例如低加工效率或规模限制等。本研究介绍了一种通过纳米纤维素基质快速驱动形成多细胞球体的方法。该方法能够快速促进多个细胞组装形成尺寸可控的多细胞微球(48小时),形成具有类似组织的生理微观结构和特征。所形成的微球的效率、尺寸和构象取决于纳米纤维素的浓度、组装细胞的数量和细胞类型的异质性。该方法可以稳定促进肿瘤类器官和肝细胞球状体的高效形成。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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