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Bio-Design and Manufacturing  2020 Vol.3 No.3 P.266-280


Heart-on-chips screening based on photonic crystals

Author(s):  Yixuan Shang, Zhuoyue Chen, Zhuohao Zhang, Yuzhi Yang, Yuanjin Zhao

Affiliation(s):  Department of Clinical Medical Engineering, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China; more

Corresponding email(s):   yangyuzhi5500@163.com, yjzhao@seu.edu.cn

Key Words:  Heart-on-chip, Photonic crystal, Self-reporting, Biosensor, Drug testing

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Yixuan Shang, Zhuoyue Chen, Zhuohao Zhang, Yuzhi Yang, Yuanjin Zhao. Heart-on-chips screening based on photonic crystals[J]. Journal of Zhejiang University Science D, 2020, 3(3): 266-280.

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author="Yixuan Shang, Zhuoyue Chen, Zhuohao Zhang, Yuzhi Yang, Yuanjin Zhao",
journal="Journal of Zhejiang University Science D",
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A1 - Yixuan Shang
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A1 - Zhuohao Zhang
A1 - Yuzhi Yang
A1 - Yuanjin Zhao
J0 - Journal of Zhejiang University Science D
VL - 3
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PB - Zhejiang University Press & Springer
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DOI - 10.1007/s42242-020-00073-9

Recently, organ-on-chips have become a fast-growing research field with the widespread development of microfluidic chips and synthetic materials in tissue engineering. Due to the existing cardiotoxicity of many cardiovascular drugs, heart-on-chips which are promising to replace traditional animal models have been extensively researched and developed to mimic human organ functions in vitro. The heart-on-chips mainly focus on cardiac mechanics, which is regarded as the central indicator of in vitro heart models and drug testing. Traditional methods for the detection of myocardial mechanics have been demonstrated complex and inefficient in heart-on-chips. Therefore, photonic crystal materials with unique optical properties have attracted interests and have been introduced into the heart-on-chips, developing a visualized self-reporting system for cardiomyocytes activity monitoring. In this review, photonic crystal-based heart-on-chips for biosensing are introduced, as well as the fabrication methods and design criteria of them. The characterizations of the photonic crystal materials are classified into optical properties and structural properties, and their applications in cell culture and biosensing are further discussed. Then, several representative examples and developments of the integration of photonic crystal materials into microfluidic chips are described in detail. Finally, potentials and limitations are put forward to promote the development of the photonic crystal-based intelligent heart-on-chips.

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