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On-line Access: 2020-07-09

Received: 2020-04-14

Revision Accepted: 2020-06-16

Crosschecked: 2020-08-29

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Bio-Design and Manufacturing  2020 Vol.3 No.4 P.361-372

http://doi.org/10.1007/s42242-020-00085-5


3D bioprinted breast tumor model for structureactivity relationship study


Author(s):  Xiaorui Li, Quanfeng Deng, Tiantian Zhuang, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin, Yong Luo & Xiuli Zhang

Affiliation(s):  Present Address: State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Sciences, School of Chemical Engineering, Dalian University of Technology, Dalian, China; more

Corresponding email(s):   bclin@dicp.ac.cn, yluo@dlut.edu.cn, zhangxl@suda.edu.cn

Key Words:  Biomaterial, Structureactivity relationship, Hydroxyethyl cellulose


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Xiaorui Li, Quanfeng Deng, Tiantian Zhuang, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin, Yong Luo & Xiuli Zhang. 3D bioprinted breast tumor model for structureactivity relationship study[J]. Journal of Zhejiang University Science D, 2020, 3(4): 361-372.

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author="Xiaorui Li, Quanfeng Deng, Tiantian Zhuang, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin, Yong Luo & Xiuli Zhang",
journal="Journal of Zhejiang University Science D",
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pages="361-372",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-020-00085-5"
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A1 - Weijie Zhao
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Abstract: 
In this paper, we present a 3D printed tumor spheroidal model suitable for drug discovery. This model is based on a hydroxyethyl cellulose/alginate/gelatin (HCSG) composite biomaterial that has three distinct properties: (1) the HCSG is similar to the commercial basement membrane extract in Ki67, MUC1, and PARP1 expressions of MCF-7 cells for embedding culture; (2) the HCSG is printable at room temperature; and (3) the HCSG can be large-scale manufactured at an ultralow cost. We printed a 3D MCF-7 spheroid model with HCSG and characterized it in terms of cell viability, spheroid size, key protein expression, and mitochondrial metabolic activity. We used the 3D MCF-7 spheroid model to evaluate the anti-breast cancer activity of 13 amino acid-based flavone phosphoramidates and found that the alanine structure induced a stronger drug resistance, whereas phenylalanine hardly caused drug resistance in the MCF-7 cells. This is the first time that 3D bioprinting technology has been used in a structureactivity relationship study.

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