JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.5 P.342-347

Association between TaqIB polymorphism of cholesteryl ester transfer protein and coronary artery disease in the Chinese population

Author(s): Qi Yu, En-qi Liu, Si-hai Zhao, Ya-feng Li, Yan-li Wang, Yu-long Chen, Ke-na Wei, Bing-qiao Huang, Jian-lin Fan, Peng-hui Yang
Affiliation(s): Research Institute of Atherosclerotic Disease, Xi�an Jiaotong University School of Medicine, Shaanxi 710061, China; more
Corresponding email(s): sihaizhao@mail.xjtu.edu.cn
Key Words: Cholesteryl ester transfer protein, Coronary artery disease, Polymorphism, Chinese population

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Abstract: Objective: To assess whether the TaqIB polymorphism of cholesteryl ester transfer protein (CETP) is associated with coronary artery disease (CAD) in chinese population, we performed a meta-analysis in this paper. Methods: We searched PubMed, Embase, the Science Citation Index (SCI), the China Biological Medicine database (CBM), the China National Knowledge Infrastructure (CNKI), and the Wanfang database for relevant articles. Data were extracted, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: The literature search yielded 448 studies, in which 10 case-control studies including 1694 cases and 1456 controls matched the selection criteria. The combined B1 and B2 allele frequencies were 0.587 and 0.413, respectively. The pooled OR was 1.10 (95% CI, 0.89–1.34) for comparing the B1B1 or B1B2 carriers with B2B2 carriers, and was 1.27 (95% CI, 1.09–1.49) in the B1B1 carriers versus B2B2 or B1B2 carriers. Conclusions: In the present study, the TaqIB polymorphism of CETP was found to be associated with CAD in the chinese population.

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