Full Text:   <960>

Summary:  <51>

CLC number: 

On-line Access: 2025-07-28

Received: 2023-12-27

Revision Accepted: 2024-09-12

Crosschecked: 2025-07-28

Cited: 0

Clicked: 883

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jinya LIN

https://orcid.org/0009-0003-1646-6876

Jie SUN

https://orcid.org/0000-0001-7835-3656

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2025 Vol.26 No.7 P.708-712

http://doi.org/10.1631/jzus.B2300940


A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis


Author(s):  Jinya LIN, Rending WANG, Yuanyuan ZHU, Weijia HUANG, Jie SUN

Affiliation(s):  Bone Marrow Transplantation Centre, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   jsun1492@gmail.com

Key Words:  Eosinophilic granulomatosis with polyangiitis (EGPA), Idiopathic hypereosinophilic syndrome (I-HES), Cardiac arrest, Spontaneous renal hemorrhage


Share this article to: More <<< Previous Article|

Jinya LIN, Rending WANG, Yuanyuan ZHU, Weijia HUANG, Jie SUN. A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis[J]. Journal of Zhejiang University Science B, 2025, 26(7): 708-712.

@article{title="A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis",
author="Jinya LIN, Rending WANG, Yuanyuan ZHU, Weijia HUANG, Jie SUN",
journal="Journal of Zhejiang University Science B",
volume="26",
number="7",
pages="708-712",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300940"
}

%0 Journal Article
%T A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis
%A Jinya LIN
%A Rending WANG
%A Yuanyuan ZHU
%A Weijia HUANG
%A Jie SUN
%J Journal of Zhejiang University SCIENCE B
%V 26
%N 7
%P 708-712
%@ 1673-1581
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300940

TY - JOUR
T1 - A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis
A1 - Jinya LIN
A1 - Rending WANG
A1 - Yuanyuan ZHU
A1 - Weijia HUANG
A1 - Jie SUN
J0 - Journal of Zhejiang University Science B
VL - 26
IS - 7
SP - 708
EP - 712
%@ 1673-1581
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300940


Abstract: 
eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multi-system disease that presents significant diagnostic challenges due to its complexity and low incidence (White and Dubey, 2023). It affects males and females equally, though males may exhibit more active disease at diagnosis and often require more aggressive treatment (Liu et al., 2023). The hallmark features of EGPA include delayed-onset asthma, eosinophilia in tissues and blood, and vasculitis affecting small to medium-sized arteries (White and Dubey, 2023). EGPA falls under the category of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), whereas only about half of EGPA patients test positive for ANCA (Khoury et al., 2023).

一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告:强调嗜酸性肉芽肿性多血管炎早期诊断的重要性

林瑾娅1,王仁定2,朱园园1,黄维加1,孙洁1
1浙江大学医学院附属第一医院骨髓移植中心,中国杭州市,310003
2浙江大学医学院附属第一医院肾脏病中心,中国杭州市,310003
摘要:嗜酸性肉芽肿性多血管炎(EGPA)是一种罕见的多系统性疾病,其诊断充满挑战,尤其是在病情复杂且发病率低的情况下。本文报告了一例58岁男性患者,既往有10年哮喘病史和1年特发性嗜酸性粒细胞增多症(I-HES)病史。患者因持续性嗜酸性粒细胞增多并伴随心脏骤停和自发性肾出血(SRH)而住院治疗。经心肺复苏后,患者因肾破裂出血接受了右肾切除术,肾脏活检结果显示血管闭塞及嗜酸性粒细胞浸润,最终确诊为EGPA。患者在糖皮质激素和免疫抑制剂联合治疗后取得显著疗效。本文强调了早期识别和及时干预在EGPA管理中的重要性。

关键词:嗜酸性肉芽肿性多血管炎(EGPA);特发性嗜酸性粒细胞增多症(I-HES);心脏骤停;自发性肾出血(SRH)

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]AhnT, RobertsMJ, NavaratnamA, et al., 2018. Recurrent spontaneous renal haemorrhage due to polyarteritis nodosa: a medical cause for a surgical problem. ANZ J Surg, 88(12):1347-1348.

[2]BenallegueN, LozachP, BeliznaC, et al., 2016. Acute coron

[3]ary vasospasm in a patient with eosinophilic granulomatosis with polyangiitis following NSAID administration: a case report. Medicine (Baltimore), 95(47):e5259.

[4]BondM, FagniF, MorettiM, et al., 2022. At the heart of eosinophilic granulomatosis with polyangiitis: into cardiac and vascular involvement. Curr Rheumatol Rep, 24(11):337-351.

[5]EmmiG, BettiolA, GelainE, et al., 2023. Evidence-based guideline for the diagnosis and management of eosinophilic granulomatosis with polyangiitis. Nat Rev Rheumatol, 19(6):378-393.

[6]Garcia-VivesE, Rodriguez-PalomaresJF, HartyL, et al., 2021. Heart disease in eosinophilic granulomatosis with polyangiitis (EGPA) patients: a screening approach proposal. Rheumatology (Oxford), 60(10):4538-4547.

[7]GibsonLE, 2022. Cutaneous manifestations of antineutrophil cytoplasmic antibody-associated vasculitis (AAV): a concise review with emphasis on clinical and histopathologic correlation. Int J Dermatol, 61(12):1442-1451.

[8]GuillevinL, PagnouxC, SerorR, et al., 2011. The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort. Medicine (Baltimore), 90(1):19-27.

[9]KhouryP, AkuthotaP, KwonN, et al., 2023. HES and EGPA: two sides of the same coin. Mayo Clin Proc, 98(7):1054-1070.

[10]LiuSY, GuoL, FanXY, et al., 2021. Clinical features of central nervous system involvement in patients with eosinophilic granulomatosis with polyangiitis: a retrospective cohort study in China. Orphanet J Rare Dis, 16:152.

[11]LiuSY, HanLN, LiMT, et al., 2023. Sex differences in clinical manifestations of hospitalized patients with eosinophilic granulomatosis with polyangiitis: a retrospective cohort study. J Rheumatol, 50(10):1318-1325.

[12]NothI, StrekME, LeffAR, 2003. Churg-Strauss syndrome. Lancet, 361(9357):587-594.

[13]ReggianiF, L'ImperioV, CalatroniM, et al., 2023. Renal involvement in eosinophilic granulomatosis with polyangiitis. Front Med, 10:1244651.

[14]SakuraiY, OshikataC, KatayamaT, et al., 2023. A case of eosinophilic polyangiitis with granulomatosis that evolved to cardiac arrest due to advanced atrioventricular block. Nagoya J Med Sci, 85(1):171-178.

[15]WhiteJ, DubeyS, 2023. Eosinophilic granulomatosis with polyangiitis: a review. Autoimmun Rev, 22(1):103219.

[16]ZhaoΒ, ZhengHM, YangTF, et al., 2023. Eosinophilic granulomatosis with polyangiitis in allergic asthma: efforts to make early diagnosis possible. Allergy Asthma Proc, 44(1):59-63.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2025 Journal of Zhejiang University-SCIENCE