Infra-slow body-surface potentials show a group-level association with thyroid cancer
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Bohan DENG, Ruili ZHANG, Yuxuan LIU, Jinglao LIN, Shicong GUI, Xihao WEI, Yin CHENG, Li ZHENG, Shaohua HU, Pingping LYU, Yubo LI, Huafen WANG. Infra-slow body-surface potentials show a group-level association with thyroid cancer[J]. Journal of Zhejiang University Science B, 2026, 27(4): 426-430.
@article{title="Infra-slow body-surface potentials show a group-level association with thyroid cancer",
author="Bohan DENG, Ruili ZHANG, Yuxuan LIU, Jinglao LIN, Shicong GUI, Xihao WEI, Yin CHENG, Li ZHENG, Shaohua HU, Pingping LYU, Yubo LI, Huafen WANG",
journal="Journal of Zhejiang University Science B",
volume="27",
number="4",
pages="426-430",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2600040"
}
%0 Journal Article
%T Infra-slow body-surface potentials show a group-level association with thyroid cancer
%A Bohan DENG
%A Ruili ZHANG
%A Yuxuan LIU
%A Jinglao LIN
%A Shicong GUI
%A Xihao WEI
%A Yin CHENG
%A Li ZHENG
%A Shaohua HU
%A Pingping LYU
%A Yubo LI
%A Huafen WANG
%J Journal of Zhejiang University SCIENCE B
%V 27
%N 4
%P 426-430
%@ 1673-1581
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2600040
TY - JOUR
T1 - Infra-slow body-surface potentials show a group-level association with thyroid cancer
A1 - Bohan DENG
A1 - Ruili ZHANG
A1 - Yuxuan LIU
A1 - Jinglao LIN
A1 - Shicong GUI
A1 - Xihao WEI
A1 - Yin CHENG
A1 - Li ZHENG
A1 - Shaohua HU
A1 - Pingping LYU
A1 - Yubo LI
A1 - Huafen WANG
J0 - Journal of Zhejiang University Science B
VL - 27
IS - 4
SP - 426
EP - 430
%@ 1673-1581
Y1 - 2026
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2600040
Abstract: thyroid cancer is a common malignancy with broad systemic endocrine and metabolic effects (Hammond et al., 2024). Regarding diagnostics, if infra-slow body-surface potential (BSP) features reflect a systemic state, then this type of cancer is a reasonable clinical test case. Prior electrodermal work has focused on faster transients above 0.5 Hz (Boucsein, 2012; Posada-Quintero and Chon, 2020), and task-state skin potential abnormalities have been shown to distinguish mood disorders from healthy controls (Lyu et al., 2024). We concentrated on an infra-slow band from 0.025 to 0.2 Hz, called Band 1 herein. We evaluated whether infra-slow features carry reproducible group-level information when artifacts are explicitly controlled, with one pre-specified primary endpoint. “Separable” here means a group-level statistical difference, not individual-level diagnosis. In a cohort of 321 cancer patients, Band 1 energy showed a clear group-level association with thyroid cancer, which persisted after automated quality control (QC) and under stricter artifact-removal settings.
[1]BoucseinW,2012.Electrodermal Activity.2nd Ed. Springer, New York, USA.
[2]HammondNG,CameronRB,FaubertB,2024.Beyond glucose and Warburg: finding the sweet spot in cancer metabolism models.npj Metab Health Dis,2:11.
[3]LyuHL,HuangHM,HeJD,et al.,2024.Task-state skin potential abnormalities can distinguish major depressive disorder and bipolar depression from healthy controls.Transl Psychiatry,14:110.
[4]Posada-QuinteroHF,ChonKH,2020.Innovations in electrodermal activity data collection and signal processing: a systematic review.Sensors,20(2):479.
[5]ZhangL,XingSC,YinHF,et al.,2024.Skin-inspired, sensory robots for electronic implants.Nat Commun,15:4777.
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On-line Access: 2026-04-24
Received: 2026-01-22
Revision Accepted: 2026-03-02
Crosschecked: 2026-04-24
Cited: 0
Clicked: 351
Citations: Bibtex RefMan EndNote GB/T7714
https://orcid.org/0009-0008-7523-0421
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