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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.2 P.151~156


Mathematical model of the dynamics of countercurrent chromatography

Author(s):  LU Xiang-hong, REN Qi-long, WU Ping-dong

Affiliation(s):  National Laboratory of Secondary Resources Chemical Engineering, Zhejiang University, Hangzhou, China, 310027

Corresponding email(s):   Luxh1971@263.net

Key Words:  Countercurrent chromatography, Model simulation, Caffeine, Theophylline

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LU Xiang-hong, REN Qi-long, WU Ping-dong. Mathematical model of the dynamics of countercurrent chromatography[J]. Journal of Zhejiang University Science A, 2002, 3(2): 151~156.

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T1 - Mathematical model of the dynamics of countercurrent chromatography
A1 - LU Xiang-hong
A1 - REN Qi-long
A1 - WU Ping-dong
J0 - Journal of Zhejiang University Science A
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DOI - 10.1631/jzus.2002.0151

A mathematical model of the dynamic behavior of countercurrent chromatography was proposed, and the model parameters, including the partition coefficient, the axial dispersion coefficient, the intraparticle diffusion coefficient and the external mass ransfer coefficient were calculated by the method of chromatogram moment analysis. Comparison of the experimental chromatograms of caffeine and theophylline determined in this work with the simulated curves computed by the proposed model showed fairly good agreement. Further, the difference between the average identified the partition coefficients by chromatogram moment analysis and the experimental values was small also, and the relationship between the external mass transfer rate and the linear velocity was similar to that obtained with solid-liquid chromatography.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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