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Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.8 P.1001~1004

http://doi.org/10.1631/jzus.2004.1001


Effect of lead exposure on the immune function of lymphocytes and erythrocytes in preschool children


Author(s):  ZHAO Zheng-yan, LI Rong, SUN Li, LI Zhi-yu, YANG Ru-lai

Affiliation(s):  Affiliated Children's Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   zhaozy@zju.edu.cn

Key Words:  Children, Lead exposure, Lymphocyte immunity, Erythrocyte immunity


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ZHAO Zheng-yan, LI Rong, SUN Li, LI Zhi-yu, YANG Ru-lai. Effect of lead exposure on the immune function of lymphocytes and erythrocytes in preschool children[J]. Journal of Zhejiang University Science A, 2004, 5(8): 1001~1004.

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author="ZHAO Zheng-yan, LI Rong, SUN Li, LI Zhi-yu, YANG Ru-lai",
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year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.1001"
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%A ZHAO Zheng-yan
%A LI Rong
%A SUN Li
%A LI Zhi-yu
%A YANG Ru-lai
%J Journal of Zhejiang University SCIENCE A
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.1001

TY - JOUR
T1 - Effect of lead exposure on the immune function of lymphocytes and erythrocytes in preschool children
A1 - ZHAO Zheng-yan
A1 - LI Rong
A1 - SUN Li
A1 - LI Zhi-yu
A1 - YANG Ru-lai
J0 - Journal of Zhejiang University Science A
VL - 5
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SP - 1001
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%@ 1869-1951
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2004.1001


Abstract: 
Objective: To investigate the influence of lead exposure on the immune function of lymphocytes and erythrocytes in preschool children. Materials and methods: A group of 217 children three to six years of age from a rural area were given a thorough physical examination and the concentration of lead in blood samples taken from each subject was determined. The indices of lymphocyte immunity (CD+3CD+4, CD+3CD+8, CD+4CD+8, CD-3CD+19) and erythrocyte immunity (RBC-C3b, RBC-IC, RFER, RFIR, CD35 and its average fluorescence intensity) of 40 children with blood lead levels above 0.483 μmol/L were measured and compared with a control group. Results: The blood lead levels of the 217 children ranged from 0.11 μmol/L to 2.11 μmol/L. The CD+3CD+4and CD+4CD+8 cells were lower (P<0.01) and the CD+3CD+8 cells were higher in the lead-poisoned subjects than those in the control group (P<0.05). CD+8 and CD-3CD+19 did not show significant differences. Although the RBC-C3b rosette forming rate was lower and the RBC-IC rosette forming rate was higher in the lead-poisoned group, this difference could not be shown to be statistically significant (P>0.05). RFIR was found to be lower in the lead-poisoned group (P<0.01). Compared with the control group, the positive rate of CD35 was not found to be significantly different in a group of 25 lead-poisoned children (P>0.05), while the average fluorescence intensity was lower in the lead-poisoned group (P<0.05). Conclusion: lead exposure can result in impaired immune function of T lymphocytes and erythrocytes in preschool children.

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Reference

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