Full Text:   <1244>

CLC number: R725.8

On-line Access: 

Received: 2005-07-07

Revision Accepted: 2005-09-07

Crosschecked: 0000-00-00

Cited: 10

Clicked: 4346

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.12 P.1206~1209

10.1631/jzus.2005.B1206


Treatment and follow-up of children with transient congenital hypothyroidism


Author(s):  YANG Ru-lai, ZHU Zhi-wei, ZHOU Xue-lian, ZHAO Zheng-yan

Affiliation(s):  Affiliated Children’ more

Corresponding email(s):   zhaozy@zju.edu.cn

Key Words:  Transient congenital hypothyroidism, Levothyroxine, Development quotient, Follow-up


YANG Ru-lai, ZHU Zhi-wei, ZHOU Xue-lian, ZHAO Zheng-yan. Treatment and follow-up of children with transient congenital hypothyroidism[J]. Journal of Zhejiang University Science B, 2005, 6(12): 1206~1209.

@article{title="Treatment and follow-up of children with transient congenital hypothyroidism",
author="YANG Ru-lai, ZHU Zhi-wei, ZHOU Xue-lian, ZHAO Zheng-yan",
journal="Journal of Zhejiang University Science B",
volume="6",
number="12",
pages="1206~1209",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B1206"
}

%0 Journal Article
%T Treatment and follow-up of children with transient congenital hypothyroidism
%A YANG Ru-lai
%A ZHU Zhi-wei
%A ZHOU Xue-lian
%A ZHAO Zheng-yan
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 12
%P 1206~1209
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B1206

TY - JOUR
T1 - Treatment and follow-up of children with transient congenital hypothyroidism
A1 - YANG Ru-lai
A1 - ZHU Zhi-wei
A1 - ZHOU Xue-lian
A1 - ZHAO Zheng-yan
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 12
SP - 1206
EP - 1209
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B1206


Abstract: 
Objective: To study the clinical therapy and prognosis in children with transient congenital hypothyroidism (CH). Methods: Fifty-seven children with CH diagnosed after neonatal screening were treated with low-dosage levothyroxine (L-T4). follow-up evaluation included the determination of TT3, TT4 and TSH serum levels and the assessment of thyroid gland morphology, bone age, growth development and development quotients (DQ). A full check-up was performed at age 2, when the affected children first discontinued the L-T4 treatment for 1 month, and one year later. development quotients were compared with a control group of 29 healthy peers. Results: The initial L-T4 dosage administered was 3.21~5.81 μg/(kg·d) with an average of (16.25±3.87) μg/d. Mean duration of therapy was (28.09±9.56) months. No significant difference was found between study group and control group in the DQ test (average score (106.58±14.40) vs (102.4±8.6), P>0.05) and 96.49% of the CH children achieved a test score above 85. Bone age, 99mTc scans and ultrasonographic findings were all normal, and evaluation of physical development was normal too, as were the serum levels of TT3, TT4 and TSH after one year of follow-up. Conclusion: A L-T4 dosage of 3.21~5.81 μg/(kg·d) was found sufficient for the treatment of transient CH. The treated children showed satisfactory overall mental and physical development at age 2. So it is possible for CH children to stop taking medicine if their laboratory findings and physical development are all normal after regular treatment and 2~3 years of follow-up.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Campos, S.P., Sandberg, D.E., Barrick, C., Voorhess, M.L., MacGillivray, M.H., 1995. Outcome of lower L-thyroxine dose for treatment of congenital hypothyroidism. Clin. Pediatr., 34:514-520.

[2] Gruters, A., Liesenkotter, K.P., Zapico, M., Jenner, A., Dutting, C., Pfeiffer, E., Lehmkuhl, U., 1997. Results of the screening program for congenital hypothyroidism in Berlin (1978-1995). Exp. Clin. Endocrinol. Diabetes, 105(4):28-31.

[3] Gu, X.F., Wang, Z.G., 2004. Screeing for phenylketonuria and congenital hypothyroidism in 5.8 million neonates in China. Chin. J. Prev. Med., 38(2):99-101.

[4] Hrytsiuk, I., Gilbert, R., Logan, S., Pindoria, S., Brook, C.G., 2002. Starting dose of levothyroxine for the treatment of congenital hypothyroidism: a systematic review. Arch. Pediatr. Adolesc. Med., 156:485-491.

[5] Hsiao, P.H., Chiu, Y.N., Tsai, W.Y., Su, S.C., Lee, J.S., Soong, W.T., 2001. Intellectual outcome of patients with congenital hypothyroidism detected by neonatal screening. J. Formos. Med. Assoc., 100(1):40-44.

[6] Oerbeck, B., Sundet, K., Kase, B.F., Heyerdahlm, S., 2003. Congenital hypothyroidism: influence of disease severity and L-thyroxine treatment on intellectual, motor, and school-associated outcomes in young adults. Pediatrics, 112(4):923-930.

[7] Pasquier, S., Torresani, T., Werder, E., Gnehm, H.E., 1997. Transitory neonatal hypothyroidism caused by transplacental transfer of anti-receptor antibodies of hypophyseal thyroid simulation. Schweiz. Med. Wochenschr., 127(44):1824-1828.

[8] Peneva, L., Stoeva, I., Grigorova, R., Vassileva, B., 1997. Results of neonatal screening of congenital hypothyroidism in Bulgaria for a period of 3 years. Early Human Developmant, 49:73-77.

[9] Rovet, J.F., Ehrlich, R.M., 1995. Long-term effects of L-thyroxine therapy for congenital hypothyroidism. J. Pediatr., 126(3):380-386.

[10] Salerno, M., Militerni, R., Bravaccio, C., Micillo, M., Capalbo, D., Di, M.S., Tenore, A., 2002. Effect of different starting doses of levothyroxine on growth and intellectual outcome at four years of age in congenital hypothyroidism. Thyroid., 12(1):45-52.

[11] Wang, S.T., Pizzolato, S., Demshar, H.P., 1998. Diagnostic effectiveness of TSH and of T4 with secondary TSH screening for newborn congenital hypothyroidism. Clin. Chim. Acta, 274:151-158.

[12] Wasniewska, M., de Luca, F., Siclari, S., Salzano, G., Messina, M.F., Lombardo, F., Valenzise, M., Ruggeri, C., Arrigo, T., 2002. Hearing loss in congenital hypothalamic hypothyroidism: a wide therapeutic window. Hear Res., 172:87-91.

[13] Wu, R.P., Hu, Y.M., Jiang, Z.F., 1995. Practical Paediatrics, 6th Ed. People’s Hygiene Publishing House, Beijing, p.1944-1951 (in Chinese).

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - Journal of Zhejiang University-SCIENCE