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CLC number: R73

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Received: 2008-08-15

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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.5 P.331~340

10.1631/jzus.B0820248


Adenovirus-mediated wild-type p53 gene transfer in combination with bronchial arterial infusion for treatment of advanced non-small-cell lung cancer, one year follow-up


Author(s):  Yong-song GUAN, Yuan LIU, Qing ZOU, Qing HE, Zi LA, Lin YANG, Ying HU

Affiliation(s):  Department of Oncology, West China Hospital of Sichuan University, Chengdu 610041, China; more

Corresponding email(s):   YongsongGuan@yahoo.com

Key Words:  RAd-p53 gene therapy, Clinical trial, Non-small-cell lung cancer (NSCLC), Bronchial arterial infusion (BAI)


Yong-song GUAN, Yuan LIU, Qing ZOU, Qing HE, Zi LA, Lin YANG, Ying HU. Adenovirus-mediated wild-type p53 gene transfer in combination with bronchial arterial infusion for treatment of advanced non-small-cell lung cancer, one year follow-up[J]. Journal of Zhejiang University Science B, 2009, 10(5): 331~340.

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author="Yong-song GUAN, Yuan LIU, Qing ZOU, Qing HE, Zi LA, Lin YANG, Ying HU",
journal="Journal of Zhejiang University Science B",
volume="10",
number="5",
pages="331~340",
year="2009",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820248"
}

%0 Journal Article
%T Adenovirus-mediated wild-type p53 gene transfer in combination with bronchial arterial infusion for treatment of advanced non-small-cell lung cancer, one year follow-up
%A Yong-song GUAN
%A Yuan LIU
%A Qing ZOU
%A Qing HE
%A Zi LA
%A Lin YANG
%A Ying HU
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 5
%P 331~340
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820248

TY - JOUR
T1 - Adenovirus-mediated wild-type p53 gene transfer in combination with bronchial arterial infusion for treatment of advanced non-small-cell lung cancer, one year follow-up
A1 - Yong-song GUAN
A1 - Yuan LIU
A1 - Qing ZOU
A1 - Qing HE
A1 - Zi LA
A1 - Lin YANG
A1 - Ying HU
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 5
SP - 331
EP - 340
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820248


Abstract: 
Objective: In the present study, we have examined the safety and efficacy of recombinant adenovirus encoding human p53 tumor suppressor gene (rAd-p53) injection in patients with advanced non-small-cell lung cancer (NSCLC) in the combination with the therapy of bronchial arterial infusion (BAI). Methods: A total of 58 patients with advanced NSCLC were enrolled in a non-randomized, two-armed clinical trial. Of which, 19 received a combination treatment of BAI and rAd-p53 (the combo group), while the remaining 39 were treated with only BAI (the control group). Patients were followed up for 12 months, with safety and local response evaluated by the National Cancer Institute’s Common Toxicity Criteria and response evaluation criteria in solid tumor (RECIST), respectively. Time to progression (TTP) and survival rates were also analyzed by Kaplan-Meier method. Results: In the combo group, 19 patients received a total of 49 injections of rAd-p53 and 46 times of BAI, respectively, while 39 patients in the control group received a total of 113 times of BAI. The combination treatment was found to have less adverse events such as anorexia, nausea and emesis, pain, and leucopenia (P<0.05) but more arthralgia, fever, influenza-like symptom, and myalgia (P<0.05), compared with the control group. The overall response rates (complete response (CR)+partial response (PR)) were 47.3% and 38.4% for the combo group and the control group, respectively (P>0.05). Patients in the combo group had a longer TTP than those in the control group (a median 7.75 vs 5.5 months, P=0.018). However, the combination treatment did not lead to better survival, with survival rates at 3, 6, and 12 months in the combo group being 94.74%, 89.47%, and 52.63%, respectively, compared with 92.31%, 69.23%, and 38.83% in the control group (P=0.224). Conclusion: Our results show that the combination of rAd-p53 and BAI was well tolerated in patients with NSCLC and may have improved the quality of life and delayed the disease progression. A further study to better determine the efficacy of this combination therapy is warranted.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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