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Received: 2019-06-18

Revision Accepted: 2019-12-20

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.3 P.179-191

10.1631/jzus.B1900312


Role of LINC00152 in non-small cell lung cancer


Author(s):  Hong Yu, Shu-Bin Li

Affiliation(s):  Cell Biology Laboratory, Jilin Province Institute of Cancer Prevention and Treatment, Jilin Cancer Hospital, Changchun 130012, China; more

Corresponding email(s):   lshbbj@126.com

Key Words:  Long non-coding RNA, LINC00152, Non-small cell lung cancer, Proliferation, Prognosis


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Hong Yu, Shu-Bin Li. Role of LINC00152 in non-small cell lung cancer[J]. Journal of Zhejiang University Science B, 2020, 21(3): 179-191.

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Abstract: 
non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. The pathogenesis of NSCLC involves complex gene networks that include different types of non-coding RNAs, such as long non-coding RNAs (lncRNAs). The role of lncRNAs in NSCLC is gaining an increasing interest as their function is being explored in various human cancers. Recently, a new oncogenic lncRNA, LINC00152 (cytoskeleton regulator RNA (CYTOR)), has been identified in different tumor types. In NSCLC, the high expression of LINC00152 in tumor tissue and peripheral blood samples has been shown to be associated with worse prognoses of NSCLC patients. Overexpression of LINC00152 has been confirmed to promote the proliferation, invasion, and migration of NSCLC cells in vitro, as well as increase tumor growth in vivo. This review discusses the role of LINC00152 in NSCLC.

LINC00152在非小细胞肺癌中的作用

概要:非小细胞肺癌(NSCLC)约占所有肺癌病例的85%,其发生发展过程涉及复杂的基因调控网络,其中除了编码基因,还包括大量不同类型的非编码RNA,如长链非编码RNA(lncRNA).lncRNA在人类癌症中的作用正在被深入研究,在NSCLC中的作用也日益受到关注.最近,在不同类型的肿瘤中发现了一个新的致癌lncRNA:LINC00152(又被称为细胞骨架调节RNA).LINC00152在NSCLC患者的肿瘤组织和外周血中高表达,并与患者的不良预后相关.上调LINC00152表达已被证实在体外能促进NSCLC细胞的增殖、侵袭和迁移,并且在体内能促进裸鼠移植瘤的生长.本文综述了LINC00152在NSCLC中的作用及其机制.
关键词:长链非编码RNA;LINC00152;非小细胞肺癌;增殖;预后

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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